摘要
目的:探讨细胞粘附分子1(cell adhesion molecule 1,CADM1)在食管鳞癌中的表达及其与淋巴结转移的相关性。方法:应用免疫组织化学SP法检测60例食管鳞癌及30例正常食管组织中CADM1的表达,分析食管癌中CADM1表达与食管鳞癌淋巴结转移的关系。结果:60例食管鳞癌及30例正常食管组织CADM1阳性率分别为55.0%、100.0%,两者CADM1表达阳性率比较差异有统计学意义(χ2=19.29,P<0.01)。CADM1表达阳性率与淋巴结转移呈负相关(P<0.01)。结论:CADM1在食管鳞癌中低表达,其表达缺失与食管癌侵袭转移有关。
Objective： To investigate the r elationship between the expression of cell adhesion molecule 1 （CADM1） and lymph node metastasis in Esophageal Squamous Cell Carcinoma （ESCC）. Methods：The expression of CADM1 in 60 ESCC and 30 normal esophageal tissues were measured by immunohistochemistry, and the relationship between the expres-sion of CADM1 and lymph node metastasis in ESCC were analyzed. Results：The positive rates of CADM1 in 60 ESCC and 30 normal esophageal tissues were 55.0% and 100.0%, respectively. The positive rate of CADM1 in ESCC was lower than in normal esophageal tissues （χ2=19.29,P〈0.01）,and negatively correlated with lymph node metastasis（P〈0.01）. Conclu-sions：CADM1 was lowerly expressed in ESCC than in normal esophageal tissues. Loss expression of the CADM1 might play an important role in the metastasis and invasion of ESCC.
出处
《交通医学》
2014年第1期36-37,41,共3页
Medical Journal of Communications
关键词
食管鳞癌
细胞粘附分子1
淋巴结转移
Esophageal Squamous Cell Carcinoma
CADM1
Lymph node metastasis
