摘要
目的:研究细胞粘附分子1(cell adhesion molecule 1,CADM1)在口腔鳞状细胞癌(Oral squamous cell car-cinoma,OSCC)中的表达,探讨其在OSCC病变中的作用及其临床意义。方法:应用免疫组织化学法S-P法检测52例OSCC及30例正常的口腔黏膜组织中CADM1蛋白的表达,数据采用SPSS13.0统计软件进行χ2检验。结果:CADM1蛋白在高分化组阳性表达率为87.50%、中分化组阳性表达率为42.86%、低分化组阳性表达率为20.00%,三者之间对比有显著性差异(P<0.05),与正常对照组有显著性差异(P<0.01);在临床分期为早期(Ⅰ级+Ⅱ级)组中阳性表达率为72.22%,晚期(Ⅲ级+Ⅳ级)组中阳性表达率为35.29%,二者之间存在显著性差异(P<0.05)。结论:CADM1蛋白的表达与OSCC的病理分级、临床分期关系密切,提示CADM1蛋白缺失可能是OSCC的发生机制之一。
Objective：To detect the expression of CADM1 in human oral squamous cell carcinoma（OSCC） and to expore its clinicopathological significance.Methods：The expression of CADM1 in 52 cases of OSCC and 30 cases of normal oral squamous tissue was detected by immunohistochemistry using S-P staining.The correlation of each score according to the intensity and percentage of labelled cells or intercellular substance with relevant clinical date was statistically analyzed by SPSS13.0.Results：The postive rate of CADM1 in well differentiated OSCC group was 87.50 %,in moderately differentiated OSCC group was 42.86% and in poorly differentiated OSCC group was 20.00%.There were significant differences for CADM1 postive rates in different grades（P〈0.05）,and significantly higher in OSCC than that in normal oral mucosal tissue（P〈0.01）.The postive rate of CADM1 in clinical early stage group was 72.22% and in clinical advanced stage group was 35.29%.There were significant differences between these two stages（P〈0.05）.Conclusion：There was significant correlation between the expression of CADM1 and OSCC generation or development,which implied that CADM1 protein loss might be one of the pathogenesis of OSCC.
出处
《口腔医学研究》
CAS
CSCD
北大核心
2011年第2期145-148,共4页
Journal of Oral Science Research
