摘要
目的 研究增殖细胞核抗原 (PCNA)在宫颈鳞癌中的表达及其意义。方法 应用免疫组化S P法检测 31例宫颈鳞癌及 10例正常宫颈组织中PCNA表达。结果 宫颈鳞癌PCNA强阳性率为 6 1 3 % ,正常宫颈组织均为弱阳性 ,两者差异有显著性 (P <0 0 5 ) ,PCNA强阳性表达与组织学分级有关 (P <0 0 5 )而与其它临床病理因素无关 (P >0 0 5 )。
Objective To study the significance and expression of proliferating cell nuclear antigen (PCNA)in squamous cell carcinoma of cervix. Methods Using immunohistochemistry S P method, PCNA was examined in 31 case of squamous cell carcinomas and 10 cases of normal cervical tissues. Results The strong positive rate of PCNA was 61 3% in cervical squamous cell carcinomas.Weak positivity was seen in all normal cervical tissues. There was significant difference between squamous cell carcinomas and normal cervical tissues ( P <0 05). The expressions of PCNA were related to the differentiation of squamous cell carcinomas in cervix, but no relationship was found between PCNA and other clinic pathological factors ( P >0 05). Conclusion Our data indicates that examination of PCNA assist in evaluating proliferating activity and prognosis of cervical squamous cell carcinomas.
出处
《安徽医科大学学报》
CAS
2000年第6期447-448,共2页
Acta Universitatis Medicinalis Anhui
关键词
病理学
增殖细胞核抗原
宫颈鳞状细胞癌
基因表达
cervix neoplasms/pathol
carcinoma,squamous cell
proliferating cell nuclear antigen
