摘要
背景:药物治疗骨关节炎不理想,近年来越来越多的研究在尝试采用干细胞移植治疗骨关节炎。目的:综述分析干细胞治疗骨关节炎及其临床应用、和存在的障碍。方法:由第一作者应用计算机检索PubMed、中国期刊全文数据库(CNKI)1998年3月至2013年10月相关文献。在PubMed检索中输入英文单词"stem cell,Osteoarthritis,bone metabolism,bone marrow mesenchymal stem cells"之间以"AND"形式检索,在中国期刊全文数据库中输入主题词"干细胞,骨关节炎,骨代谢,骨髓间充质干细胞"之间以"并且"关系为检索词选择模糊查询进行检索。选择文章内容与干细胞治疗骨关节炎有关者,同一领域文献则选择近期发表在权威杂志文章。结果与结论:初检得到79篇文献,选择了符合纳入标准的50篇文献进行综述。应用干细胞治疗骨关节炎,其治疗目的主要是通过促进软骨组织修复来达到,使用的方法是干细胞移植及诱导干细胞分化。干细胞可以治疗骨关节炎,具有广阔应用前景。
BACKGROUND：Nowadays treatment of osteoarthritis with drugs is not ideal. In recent years, more and more scientists try to use stem cells to treat osteoarthritis.OBJECTIVE：To explore the stem celltreatment for osteoarthritis in order to promote its clinical application and find out its difficulties.METHODS：A computer-based online search of PubMed database and CNKI database between March 1998 and October 2013 was performed to search related articles with the key words of“stem cell, osteoarthritis, bone metabolism, bone marrow mesenchymal stem cells”in English or in Chinese, respectively. The word“AND”was used for the connection between the word retrieval. Literatures related to stem cells treatment for osteoarthritis were selected;in the same field, the articles published lately in authoritative journals were preferred. RESULTS AND CONCLUSION：A total of 79 literatures were primarily selected, and 50 documents were involved for summary according to inclusion criteria. The stem celltreatment for osteoarthritis is realized mainly by promoting the repair of cartilage tissue. Commonly used methods are stem celltransplantation and induced differentiation of stem cells. Stem celltreatment has broad application prospects for the treatment of osteoarthritis.
出处
《中国组织工程研究》
CAS
CSCD
2014年第6期968-973,共6页
Chinese Journal of Tissue Engineering Research
