摘要
背景:肝移植排斥反应的发病机制主要是T细胞介导的免疫应答,具有调节细胞功能的高活性、多功能的低分子蛋白质即细胞因子在器官移植排斥反应和免疫耐受中发挥着重要作用。目的:就T淋巴细胞与肝移植后免疫耐受的关系及研究现状作一综述。方法:由第一作者检索Medline数据库及维普医学数据库1995年1月至2013年6月有关肝移植后免疫状态与T淋巴细胞及其细胞因子作用的文献。以"liver transplantation,immune tolerance,rejection,T lymphocytes"为英文检索词,"肝移植,排斥反应,免疫耐受,T淋巴细胞"为中文检索词,排除重复研究类文章。选取相关文献查找全文,纳入57篇,其中有关T淋巴细胞与移植后免疫状态研究背景的文献9篇,有关调节性T细胞在移植免疫中的作用10篇,有关T淋巴细胞与移植后免疫耐受关系的文献17篇,有关T淋巴细胞与移植后免疫耐受研究前景的文献21篇。结果与结论:T淋巴细胞是调节机体免疫应答一类重要的免疫细胞。接受同种异体肝移植后,受体发生免疫排斥还是免疫耐受与免疫系统中T淋巴细胞的亚群及其功能密切相关。通过阻断或诱导T淋巴细胞的某些功能可以诱导宿主免疫耐受。
BACKGROUND： Pathogenesis of liver graft rejection is mainly the immune response mediated by T cells. Low-molecular-weight proteins with high activity and multiple functions that can regulate cell functions, i.e. cytokines, exert an important role in organ-graft-rejection and immune tolerance. OBJECTIVE： To review the relation and current research of T lymphocytes and immune tolerance of liver transplantation. METHODS： A computer-based online search was conducted by the first author in Medline and VIP Database from January 1995 to June 2013 for articles concerning immune state after liver transplantation, T lymphocytes and its cytokines. The key words were ~liver transplantation, immune tolerance, rejection, T lymphocytes＂. Duplicated studies were excluded. Full texts were searched. A total of 57 related articles were accepted. Nine articles concerned the background research of T lymphocytes with immune status after transplantation. Ten articles addressed the role of regulatory T cells in transplantation immunology. Seventeen articles were about the relation of T lymphocytes and immune tolerance after transplantation. Twenty-one articles were on the research prospects of T lymphocytes and immune tolerance after transplantation. RESULTS AND CONCLUSION＂ T lymphocytes are important cells to regulate the immune response. Immunologic rejection or immune tolerance depended on subsets and functions of T lymphocyte in the immune system after receiving allogeneic liver transplantation. We can induce host immune tolerance through inhibition orinduction of some features of T lymphocytes.
出处
《中国组织工程研究》
CAS
CSCD
2014年第5期791-796,共6页
Chinese Journal of Tissue Engineering Research
