摘要
DNA拓扑异构酶是真核细胞和原核细胞中的一种基本酶,广泛存在于细胞核中,对DNA的转录、复制以及基因表达过程中的DNA拓扑结构的改变起着重要的作用。研究发现DNA拓扑异构酶在肿瘤组织中高度表达,许多抗肿瘤药物的作用机制与抑制拓扑异构酶有关,目前拓扑异构酶已成为筛选抗肿瘤药物的重要靶点。
DNA topoisomerases are ubiquitous enzymes in eukaryotic cell and prokaryotic cell. They are widely existing in the nucleus and playing a crucial role in cellular genetic processing, such as transcription, replication and gene expression. Recent studies show that, topoisomerases are over expressed in cancer cell and thus they have become the important targets for screening of antitnmor drug.
出处
《大学化学》
CAS
2014年第1期1-10,共10页
University Chemistry
关键词
DNA拓扑异构酶
抑制剂
抗肿瘤药物
DNA topoisomerase
DNA topoisomerase inhibitor
anticancer drug
