摘要
目的观察细胞因子诱导的杀伤细胞对维持治疗中晚期肺癌患者的临床疗效。方法选取49例接受化疗联合CIK进行治疗的中晚期肺癌患者作为实验组,49例同期接受单纯化疗的中晚期肺癌患者作为对照组。结果治疗后的2、4和8周实验组CD+3、CD+4T细胞、CD+4/CD+8比值以及细胞因子IL-2和IFN-γ均比同期对照组显著增加;治疗后,实验组的有效率为48.97%,控制率为89.80%,对照组的有效率为8.16%,控制率为51.02%;实验组中癌症类型以及是否合并转移对临床疗效影响显著,各结果差异显著。结论细胞因子诱导的杀伤细胞能够显著提高中晚期肺癌患者的临床疗效。
Objective To observe the curative effect of cytokine-induced killer cells for the maintenance treatment of patients with advanced lung cancer. Methods 49 patients with advanced lung cancer as the experiment group received chemotherapy combined with CIK, and another 49 patients at the same period received chemotherapy alone as the control group. Results 2, 4 and 8 weeks after the treatment, the levels of CD＋3, CD＋4 T cells, CD＋4/CD＋8 and cytokines IL-2 and IFN-γ were higher in the experiment group than in the control group. The effective rate was 48.97 % and the control rate was 89.80% in the experiment group, and the effective rate was 8.16% and the control rate was 51.02% in the control group. The type of cancer and metastasis showed great influence on curative effect. Conclusion Cytokine-induced killer cells can significantly improve the clinical efficacy in patients with advanced lung cancer.
出处
《临床肺科杂志》
2014年第4期706-709,共4页
Journal of Clinical Pulmonary Medicine
关键词
CIK
中晚期肺癌
临床观察
影响因素
CIK
advanced lung cancer
clinical observation
influencing factors
