摘要
血管内皮生长因子(VEGF)是近年研究较广泛的参与内皮细胞活化和血管生成的重要因子,它通过与其特异性受体结合发挥生物学作用。缺氧诱导因子-1α(HIF-1α)是缺氧条件下被激活,参与肿瘤发生、发展的一类核转录因子,通过激活下游基因发挥促进肿瘤血管生成的作用。葡萄糖转运蛋白(GULT-1)是新近研究发现的与子宫内膜癌血管生成相关的因子。血小板衍化生长因子(PDGF)一类重要的促有丝分裂多肽生长因子。其在肿瘤血管新生中的作用有待于进一步研究。目前许多研究发现,以上几种因子与子宫内膜癌关系密切,直接或间接参与了子宫内膜癌的病理生理过程。对这几种因子的深入研究将为子宫内膜癌的防治与抗血管生成治疗提供新的理论依据及治疗靶点。
Vascular endothelial growth factor （VEGF） is an important factor which is widespread studied in endothelial cell activation and angiogenesis via its specific receptors. Hypoxia-inducible factor-la （HIF-la）, a nuclear transcription factor, participate in tumorigenesis through activating downstream genes, which is activated under the condition of anaerobic.Glucose transporters （GULT-1） is also found that play an important role in endometrial carcinoma angiogenesis. Platelet derived endothelial cell growth factor （PDGF）, which promoting mitotic polypeptide growth, its role in tumor angiogenesis need to be fiarther solved. It is proved that they are closely related to endometrial cancer and participate in the pathophysiologic process of endometrial carcinoma directly or indirectly. To study these factors thoroughly would provide a new target for prevention and treatment of endometrial cancer.
出处
《现代生物医学进展》
CAS
2014年第9期1790-1792,共3页
Progress in Modern Biomedicine
基金
教育部中国博士后基金(20100471000)
关键词
子宫内膜癌
血管生成
新生血管形成
Endomertioid Carcinoma
Angiogenesis
Neovascularization
