摘要
目的本文旨在探讨miR-124在胶质瘤组织中的表达及临床意义。方法收集2010年8月—2013年5月胶质瘤患者手术切除标本45例,脑外伤或尸检脑组织共12例作为正常对照,运用原位杂交技术检测胶质瘤组织及正常脑组织中miR-124的表达水平,分析其与胶质瘤临床参数的关系。结果原位杂交检测显示,在45例胶质瘤组织中miR-124阳性表达率为28.9%(13/45例),对照组阳性表达率为75.0%(9/12例),差异有统计学意义,并且miR-124的表达随着胶质瘤患者临床分期进展而降低。结论 miR-124可能成为胶质瘤患者病情进展预测的潜在生物学标志。
Objetive To investigate the expression and chnical significance of miR-124 in glioma tissues. Methods 45 glioma tis- sue specimens and 12 brain samples from trauma or autopsy were collected from Aug 2010 to May 2013. Hybridization in situ was performed to test the expression of miR-124. Results The positive expression rate of miR-124 was 28.9% in glioma tissues and 75.0% in normal brain tissues. The downregulation of miR-124 expression was associated with the progression of clinical stage. Conclusion MiR-124 could be regarded as a potential biomarker in predicting the progression in glioma.
出处
《中国卫生产业》
2014年第6期10-11,共2页
China Health Industry
