摘要
目的观察三联疗法对老年幽门螺杆菌胃炎患者血清白细胞介素(IL)-10、转化生长因子-β1(TGF-β1)及IL-17水平的影响。方法将入选的90例老年幽门螺杆菌胃炎患者分为观察组和对照组,每组45例,观察组患者给予标准三联疗法进行治疗,对照组患者单独给予奥美拉唑治疗,治疗14d后,采用酶联免疫吸附法检测两组患者治疗前后血清IL-10、TGF-β1和IL-17水平。结果与治疗前比较,两组患者治疗后血清IL-10、TGF-β1和IL-17水平显著低更显著,差异有统计学意义(P<0.05);与对照组治疗后比较,观察组治疗后血清IL-10、TGF-β1和IL-17水平降低,差异有统计学意义(P<0.05)。观察组治疗后幽门螺杆菌阴性与幽门螺杆菌阳性患者比较,血清IL-10、TGF-β1和IL-17水平明显降低,差异有统计学意义(P<0.05)。直线相关分析结果显示,两组患者治疗前血清IL-10、TGF-β1和IL-17水平间呈正相关(P<0.05)。结论三联疗法能够明显降低老年幽门螺杆菌胃炎患者血清IL-10、TGF-β1及IL-17水平,有较好的治疗作用。
Objective To observe the effect of triple therapy to the levels of serum interleukin 10 （IL）-10, transforming growth factor beta I（TGF-β1） and IL-17 in eldly patients with helicobater pylori associated gastritis. Methods 90 eldly patients with heIi- cobater pylori associated gastritis were randomly divided into observation group and control group,45 cases in each group, the ob- servation group was given standard triple therapy, the control group was separately given omeprazole treatment, after 14 days, ELISA method was used to detect the levels of serum IL-10,TGF-β1 and IL-17. Results Compared with before treatment,the lev- els of IL-10,TGF-β1 and IL-17 in of the two groups had significantly reduced after treatment（P〈0.05） ;compared with the control group after treatment,the levels of IL-10, TGF-β1 and IL-17 in observation group after treatment had significantly reduced（P〈 0.05）. Compared with helicobater pylori negative and helicobater pylori positive patients of the experimental group after treatment, the levels of IL-10,TGF-β1 and IL-17 had significantly reduced（P〈0.05）. The levels of IL-10,TGF-β1 and IL-17 in serum of pa- tients of two groups before treatment showed significantly positive correlation（P^0.05）. Conclusion The triple therapy could sig- nificant decrease the levels of serum IL-10,TGF-β1 and IL-17 ,it has good treatment effect.
出处
《重庆医学》
CAS
CSCD
北大核心
2014年第7期821-822,825,共3页
Chongqing medicine
