摘要
目的 探讨原发性肾病综合征 (PNS)并发急性肾功能衰竭 (ARF)的病理特征、治疗方法及预后。方法 回顾分析近 10年间 2 6 1例PNS中并发ARF的 2 2例患者的临床特征、病理结果、治疗方法及预后情况。结果 PNS并发ARF的发生率为 9.9% ,临床治愈好转率为 86 .4% ,需终生透析者 4.5 % ,成活率为 95 .9%。 2 2例中微小病变型肾病 (MCD )占 40 .9% ,膜增殖性肾病(MPGN)占 2 7.3 % ,其共同病理变化是小管间质病变广泛。ARF恢复及NS缓解所需时间 :肾小球病变轻微组为 (2 2 .4± 15 .3)d及 (40 .5± 2 0 .7)d ;肾小球病变较重组为 (2 4.7± 18.6 )d及 (5 7.5±19 .8)d。结论 PNS并发ARF以MCD多见 ,其预后比MPGN好。应兼顾PNS和ARF的两个环节治疗。
Objective To explore the pathologic characteristics,treatment and prognosis of primary nephritic syndrome(PNS) complicated with acute renal failure(ARF).Methods 22 cases of PNS complicated with ARF were selected from 261 cases primary nephritic syndrome in recent 10 years and retrospective analysis the their clinical characteristics, pathologic types,treatment and prognosis were analyaed retrospectively.Results The incidence of PNS complicated with ARF was 9.9%;Clinical cure rate was 86.8%;Need to dialysis all life was 4.5%;Survival rate was 95.9%. 40.9% of the 22 patients was MCD,27.1% of them was MPGN,they all have extensive tubular and interstitial lesion. The time of ARF recovery and NS regression:Mild glomerular lesion group was( 22.4±15.3) d and (40.5± 20.7 ) d;Heavier glomerular lesion group was(24.7±18.6) d and (57.5±19.8) d.Conclusions MCD is most popular in PNS complicated with ARF and its prognosis is better than MPGN. PNS and ARF must be treated together.
出处
《临床内科杂志》
CAS
北大核心
2001年第1期47-49,共3页
Journal of Clinical Internal Medicine
