摘要
以天然高分子羟丙基纤维素-聚丙烯酸(HPC-PAA)胶体微粒为模板,通过沉淀聚合法获得中空结构的聚N-异丙基丙烯酰胺-聚丙烯酸(PNIPAm-PAA)纳米胶囊,平均粒径约为500 nm;然后运用静电作用自组装法和原位还原法将Fe3O4磁性纳米粒子负载于PNIPAm-PAA纳米胶囊上,制备获得Fe3O4/PNIPAm-PAA磁性纳米复合微球,粒径约为400 nm。制得的复合微球不仅具有一定的铁磁性(饱和磁化强度为5.5(A·m2)/kg,而且对抗肿瘤药物——盐酸阿霉素(Dox)显示了较高的载药率和较好的体外缓释效果,有望成为一种新型的靶向药物载体应用于药物输送体系。
In this study, a convenient approach has been proposed for the preparation of magnetic poly （N-isopropylacrylamide）- poly （acrylic acid ） （PNIPAm-PAA） hybrid nanospheres. In the first step, hollow PNIPAm-PAA nanocapules, of which the diameter was about 500 nm, were synthesized by precipitation polymerization with hydropropylcellulose-poly （acrylic acid ） （HPC-PAA） particles as the template. In the second step, the electrostatic interaction self-assembly method and the in situ reduction method were adopted to generate the magnetic Fe3O4 nanoparticles inside the nanoepsules. Thus the magnetic Fe304/ PNIPAm-PAA hybrid nanospheres were finally obtained and the average diameter was 400 nm. In addition, a high drug loading capacity and a sustained-release behavior were presented by using anti-cancer drug Doxorubicin hydrochloride （Dox） as a hydrophilic model drug. It indicated that the Fe3O4/PNIPAm-PAA hybrid nanospheres might be used as a new magnetic-targeted drug carrier for the drug delivery system.
出处
《林产化学与工业》
EI
CAS
CSCD
北大核心
2014年第1期19-24,共6页
Chemistry and Industry of Forest Products
基金
国家国际科技合作专项项目(2011DFA32440)
国家自然科学基金资助项目(31100427)
中国林科院林业新技术所基本科研业务费专项资金(CAFINT 2010C06)
