摘要
目的：考察n-3多不饱和脂肪酸对不同饲料喂养大鼠血糖、胰岛素及血脂的影响。方法：将SD大鼠随机分成14个组，分别为：空白对照组（普通饲料喂养），高糖高脂对照组（高糖高脂饲料喂养），普通饲料喂养的α-亚麻酸和深海鱼油高、中、低剂量组，高糖高脂饲料喂养的α-亚麻酸和深海鱼油高、中、低剂量组。α-亚麻酸和深海鱼油高、中、低剂量组分别灌胃150、300、600mg／kg的α-亚麻酸和深海鱼油。连续灌胃8N后，分别对各组大鼠的血糖、胰岛素和血脂四项进行测定。结果：α-亚麻酸对不同饲料喂养大鼠的血糖、胰岛素以及血脂都没有影响。与空白对照组相比，深海鱼油能使大鼠空腹血糖浓度明显升高（p〈0．05），空腹胰岛素浓度明显降低（p〈0．05）。深海鱼油对TG和HDL-C无影响；但是深海鱼油能使高糖高脂饲料喂养大鼠的TC和LDL—C呈下降趋势，其中TC的水平下降具有显著性差异（与高糖高脂对照组相比，p〈0．05）。结论：在150～600mg／kg的灌胃剂量下，α-亚麻酸对大鼠的血糖、胰岛素以及血脂都没有影响；深海鱼油对不同饲料喂养大鼠都有抑制胰岛素分泌和升高血糖的作用，同时对高糖高脂饲料喂养导致的大鼠TC水平升高有降低作用。
Objective：To study the effect of n-3 polyunsaturated fattyacids on blood glucose,insulin and blood lipid in rats fed by different diet. Methods.SD rats were randomly divided into 14 groups including the blank control group,sucrose and fat rich control group,three a-linolenic acid groups and three deep-sea fish oil groups fed by normal diet,another three α-linolenic acid groups and three deep-sea fish oil groups fed by sucrose and fat rich diet. The α-Iinolenic acid groups and the deep-sea fish oil groups were administered respectively with α-linolenic acid and deep-sea fish oil on does of 150,300,600mg/kg by gavage. After administered for 8 consecutive weeks,the level of blood glucose,insulin and blood lipid in the rats were determined. Results.α-Iinolenic acid hadn＇t any effect on blood glucose,insulin and blood lipid of rats fed by different diet. The level of fasting blood glucose of deep-sea fish oil groups significantly increased （compared with the blank control group,p 〈0.05） ,while the level of insulin of deep-sea fish oil groups significantly decreased （compared with the blank control group,p〈0.05）. Deep-sea fish oil hadn＇t any effect on TG and HDL-C of rats. But deep-sea fish oil could make the level of TC and LDL-C of rats fed by sucrose and fat rich diet decrease,and the level of TC decreased significantly compared with sucrose and fat rich control group. Conclusion：Under the administrated dose of 150 to 600mg/kg,there wasn＇t any effect of α-Iinolenic acid on blood glucose,insulin and blood lipid of rats.Deep-sea fish oil could increase the level of fasting blood glucose and decrease the level of insulin in rats,while decreased the level of TC in rats fed by sucrose and fat rich diet.
出处
《食品工业科技》
CAS
CSCD
北大核心
2014年第6期343-346,372,共5页
Science and Technology of Food Industry
关键词
N-3多不饱和脂肪酸
血糖
胰岛素
血脂
n-3 polyunsaturated fattyacids
blood glucose
insulin
blood lipid
