摘要
目的 了解呋喃妥因对革兰阴性杆菌的抗菌活性,为临床合理使用呋喃妥因提供依据.方法 监测某医院2009年1月至2012年12月临床分离的革兰阴性杆菌5 589株；采用VITEK 2 Compact全自动细菌培养鉴定仪进行细菌鉴定和药敏试验,以Whonet 5.6软件进行数据分析.结果 大肠埃希菌和产酸克雷伯菌对呋喃妥因的抗菌活性较好（耐药率＜4.3%）,阴沟肠杆菌和肺炎克雷伯菌对呋喃妥因的抗菌活性尚好（耐药率25.6%～36.3%）,铜绿假单胞菌、鲍曼不动杆菌、奇异变形菌和黏质沙雷菌对呋喃妥因的抗菌活性较差（耐药率93.7%～98.9%）,耐亚胺培南铜绿假单胞菌（IRPA）、耐碳青霉烯类抗菌药物鲍曼不动杆菌（CR-AB）和耐碳青霉烯类抗菌药物肠杆菌科细菌（CRE）对呋喃妥因的耐药率分别为100.0%（108/108）、100.0% （335/335）和96.1% （74/77）.结论 呋喃妥因对尿液、血液、脓汁和分泌物标本中分离的大肠埃希菌的抗菌活性较好；痰液标本中分离的铜绿假单胞菌和鲍曼不动杆菌对呋喃妥因的耐药率较高.
Objective To understand the antibacterial activity of nitrofurantoin from gram negative bacilli,provide the basis for clinical rational use of furan appropriate for drugs.Methods Gram negative bacilli 5 589 strains isolated from clinical were monitored between January 2009 and December 2009.VITEK 2 Compact automatic bacteria identification instrument was used for bacteria identification and drug sensitive test.Whonet 5.6 software was used for data analysis.Results E.coli and klebsiella bacteria produced acid with nitrofurantoin had good antibacterial activity （resistance to 〈 4.3%）,E.coli and klebsiella pneumoniae to with nitrofurantoin for antimicrobial activity was good （the percentages of 25.6% ～ 25.6%）,pseudomonas aeruginosa,acinetobacter baumannii,singular deformation bacteria and glue abdulrahman al saleh,bacterium antibacterial activity of furan appropriate for poorer（ni 93.7% ～ 98.9%）.Imine resistance from south pseudomonas aeruginosa （IRPA）,resistant to carbon penicillium alkene antimicrobial acinetobacter baumannii（CR-AB） and penicillium carbon alkene antimicrobial drug resistant enterobacteriaceae bacteria（CRE） with nitrofurantoin because of the percentages were 100.0% （108/108）,100.0% （335/335） and 96.1% （74/77）.Conclusion Urine,blood,pus,and secretion of primary separation of E.coli with nitrofurantoin has better antimicrobial activity; Sputum specimens of primary separation of pseudomonas aeruginosa and acinetobacter baumannii with nitrofurantoin has the high prevalence of resistance.
出处
《中国基层医药》
CAS
2014年第1期14-16,共3页
Chinese Journal of Primary Medicine and Pharmacy
基金
内蒙古自治区自然科学基金项目（200711020932）
关键词
耐药
呋喃妥因
革兰阴性杆菌
Drug resistance
Nitrofurantoin
Gram-negative bacteria
