摘要
腹腔注射四氧嘧啶 (ALX) 2 0 0mg/kg建立糖尿病模型小鼠 ,并随机分为 4组 ,分别用螺旋藻多糖(PSP) 10 0mg/kg、2 0 0mg/kg及阳性对照药优降糖 2mg/kg灌胃给药 ,糖尿病模型对照组则给等容积生理盐水 ,连续 14d后 ,分别测定各组小鼠血糖、血清SOD活性、MDA含量及全血GSH Px活性与GSH含量。结果与糖尿病模型对照组相比 ,PSP能使ALX所致糖尿病小鼠血糖降低 (P <0 0 1) ;血清SOD活性、全血GSH Px活性及GSH含量显著回升 (P <0 0 1) ;血清MDA含量明显下降 (P <0 0 1)。结果表明PSP能降低ALX性糖尿病小鼠高血糖并显著增强其抗氧化能力。提示PSP降血糖作用的机制可能与其增强糖尿病鼠抗氧化能力有关。
The diabetic model mice were established by intraperitoneal injection of alloxan(ALX) 200 mg/kg. Then the mice were randomly divided into four groups. Among them, two groups were given spirulina platensis polysacharide(PSP) 100 mg/kg, 200 mg/kg respectively by ig administration, and one group was received Glibenclamide 2 mg/kg by ig adminstration as the positive control, another group was given normal saline as the diabetic model control. After 14 days animals were killed to determine blood sugar, SOD, MDA, GSH Px etc. It was found that PSP could obviously decrease the blood sugar, and significantly enhance the activities of serum SOD and blood GSH Px in diabetic mice induced by ALX. In addition, the results also showed that PSP could remarkably decrease the content of serum MDA and greatly increase the concentration of blood GSH in the mice. It is suggested that PSP could decrease the level of blood sugar and effectively enhance the ability of anti oxidation in the diabetic mice induced by ALX.
出处
《药物生物技术》
CAS
CSCD
2001年第1期36-38,共3页
Pharmaceutical Biotechnology
关键词
螺旋藻多糖
四氧嘧啶
糖尿病
小鼠
抗氧化能力
Spirulina platensis polysaccharide(PSP), Alloxan(ALX), Diabetic model mice, Anti oxidation
