摘要
为探讨哮喘发作期患者血清白细胞介素 - 12 (IL - 12 )与免疫球蛋白 E(Ig E)的关系及其在哮喘发作中的作用 ,采用双抗体夹心 EL ISA方法检测了 2 7例哮喘发作期患者血清中的 IL- 12和 Ig E水平 ,并采用 SPSS统计分析软件分析了两者之间的关系。结果显示 ,2 7例患者血清中 IL - 12的平均含量 (71.70± 81.43pg/ ml)显著低于正常对照组 (196 .32± 94.33pg/ ml) ,P<0 .0 1;Ig E含量 (2 0 78.6 3± 6 11.79ng/ ml)显著高于对照组 (32 7.16±12 5 .2 8ng/ m l) ,P<0 .0 0 1。统计分析表明 ,IL - 12降低与 Ig E升高有显著相关性。提示患者体内 IL - 12产生量不足 ,可能阻碍了 Th1细胞的分化发育 ,引起了偏离的 Th2型的免疫应答 。
To evaluate the relationship and the clinical significance between the serum IL 12 and IgE in the patients with asthma in attack Sandwich ELISA was used to detect the IL 12 and IgE level in the sera of 27 cases of patients with athma in attack SPSS statical software was used to analysis the reletive of IL 12 and IgE Results showed that the serum IL 12 in 27 cases of patients with asthma in attack was 71 70±81 43pg/ml,it decresed significantly comparing with the health voluteer donor,which is 196 32±94 33pg/ml To the contrast,serum IgE in patients was 2078 63±611 79pg/ml,which significantly increaed comparing with the normal(327 16±125 28pg/ml) Linear regression showed that the decrease of IL 12 relate to the increase of IgE(R= 0 667) The results suggest that insufficient production of IL 12 imped the differenciation of Th1 Biased Th2 response may be dominat in the immune response of the asthma in attack
出处
《山东医药》
CAS
北大核心
2001年第3期6-7,共2页
Shandong Medical Journal
