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内脂素与冠心病的关系研究进展 被引量:8

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摘要 近年来研究发现,脂肪组织不仅是能量的储存器官,还作为一个代谢活跃的内分泌器官,在调节机体能量代谢平衡上发挥着极其重要的作用.脂肪组织能够产生和分泌多种生物活性物质,包括瘦素(leptin)、抵抗素(resistin)、脂联素(adiponectin)、视黄醇结合蛋白4(retinol binding protein-4,RBP4)、白介素-6 (interleukin-6,IL-6)及肿瘤坏死因子(tumor necrosis factor,TNF)-α等.内脂素(visfatin)是新发现的由内脏脂肪组织分泌的脂肪因子,有广泛的生物学功能:类胰岛素作用,调节脂类代谢,抗平滑肌细胞凋亡,促进新生血管内皮生成等.冠心病(coronary heart disease,CHD)的病理生理基础是冠状动脉粥样硬化斑块的形成.最新研究发现内脂素与动脉粥样硬化发生和发展过程相关,且在斑块的稳定性方面发挥着重要作用,已成为冠心病发病机理的研究热点之一.本文对内脂素的生理特性及其与冠心病的关系进行综述.
机构地区 成都中医药大学
出处 《现代临床医学》 2014年第1期5-8,共4页 Journal of Modern Clinical Medicine
基金 四川省卫生厅课题:课题编号110514
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参考文献30

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二级参考文献7

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