摘要
在原癌基因家族中有一类能被第二信使所诱导的基因称为即刻早期基因(IEGs)。IEGs是用丝裂原处理静止细胞时快速诱导的基因类。以c-fos和c-jun为代表的即早基因(IEG)是一类可被第二信使诱导激活的原癌基因[1],具有把短时程作用的细胞外信号和细胞功能的长时程改变偶联起来的效应,是用丝裂原处理静止细胞时快速诱导的基因类。这类基因是细胞经外部刺激后最先表达的一组基因,是联系细胞生化改变与细胞最终对刺激发生特异性反应的中介物。IEGs编码特异的DNA结合蛋白,影响靶基因转录率并参与细胞内信息的传递,将短暂的信号转为长时程的反应。因此,IEGs又被认为是第三信使。IEGs主要包括c-fos、c-jun、c-myc和egr家族。IEGs的表达与突触活动相关并在长期记忆形成和巩固的神经机制中有重要作用。研究证明多种IEGs的表达在记忆的巩固和神经可塑性机制中有十分重要的作用。
Immediate-early genes （IEG）are one of the proto-oncogene families which can be induced by second messenger genes,belonging to the rapidly induced genes when treated with static cell mitogen.Such as c-fos and c-jun, which can be activated by second messenger,can produce the coupling effect of the short-term effects of extracellular signals and the long-term changes of cell function.These genes are firstly expressed after external stimuli,are the mediator linking cell biochemical changes to cell eventually specifically reacting to stimuli.IEGs encode the specific DNA binding proteins,affect the rate of transcription of target genes,involve in the intracellular signal transmission,and convert transient signals into long-time course reaction.Therefore,IEGs are considered as the third messengers. Currently,IEGs mainly include c-fos and c-jun family,c-myc and egr families.The expression of IEGs is related to the synaptic activity,and plays an important role in formation of long-term memory and consolidation of neural mechanisms. Studies have demonstrated that the expression of many IEGs has a very important role in consolidation of memory and neural plasticity mechanisms.
出处
《检验医学》
CAS
2014年第2期174-177,181,共5页
Laboratory Medicine
关键词
即早基因
表达
铅
学习记忆
Immediate-early gene
Expression
Lead
Learning memory
