摘要
目的探讨利培酮、阿立哌唑对女性精神分裂症患者血清视黄醇结合蛋白4(BPR4)的影响及其与腹部脂肪含量及分布的关系。方法首次治疗的女性精神分裂症患者随机分组,分别接受利培酮(n=26)、阿立哌唑(n=23)治疗,疗程8周。于治疗前、治疗后4周、8周测定血清BPR4水平,同时测定腹部内脏脂肪(VA)、皮下脂肪(SA)面积、内脏脂肪/皮下脂肪比值(VA/SA)。结果①利培酮组治疗4,8周时的BPR4较治疗前显著增高(t=2.104,2.967;P<0.05,0.01);阿立哌唑治疗组无显著变化;②利培酮组治疗4,8周时VA(t=2.704,7.130;P<0.05,0.001)、VA/SA(t=2.244,6.034;P<0.05,0.001)均较治疗前增高,8周时SA较治疗前增高(t=3.132,P<0.01);阿立哌唑组VA、SA、VA/SA在治疗4周、8周时改变均不显著;③利培酮组治疗8周时的BPR4水平与VA/SA正相关(r=0.383,P<0.05)。结论利培酮可升高女性精神分裂症患者血清BPR4水平,并可能与腹部脂肪的异常分布有关,而阿立哌唑影响甚微。
Objective To explore the effects of risperidone and aripiprazole on serum level of retinol binding proteins 4 （ BPR4 ） and its relationship with abdominal fat quantity and distribution in female schizophrenic patients. Methods Female schizophrenic patients were randomly divided into two groups, receiving either risperidone （n =26） or aripiprazole （n =23） treatment for 8 weeks. Serum lev- el of retinol binding proteins and abdominal visceral adipose（ VA）, subcutaneous adipose （SA）, VA/SA ratio were determined before and after 4, 8 weeks treatment. Results At the end of 4, 8 weeks, the levels of serum BPR4 were significantly increased in risperidone group （t = 2. 104, 2. 967; P 〈 0： 05, 0.01 ） ,whereas not significantly increased in aripiprazole group （ both P 〉 0.05 ）. Significant in- creases in both VA（ t = 2. 704, 7. 130 ; P 〈 0.05, 0. 001 ） and VA/SA （ t = 2. 244, 6. 034 ; P 〈 0.05, 0. 001 ） were identified after 4, 8 weeks risperidone treatment, while the increase in SA was found to be significant only after 8 weeks （t = 3. 132, P 〈 0.01 ） treatment. There were no significant changes in VA, SA, VA/SA after aripiprazole treatment（ all P 〉 0.05 ）. The correlation between RBP4 and VA/SA at the end of 8 weeks in risperidone group was significant （r = 0. 372,P 〈 0. 05）. Conclusio Risperidone may result in an aug- ment of BPR4 which is associated with abnormal abdominal fat distribution in female schizophrenic patients however , aripiprazole may have hardly effects .
出处
《中国健康心理学杂志》
2014年第1期9-11,共3页
China Journal of Health Psychology
