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老年代谢综合征与瘦素水平的相关性分析 被引量:1

The Correlation Analysis of Serum Leptin Level and Metabolic Syndrome in the Old
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摘要 目的:本研究通过分析瘦素(Lep)与老年代谢综合征(MS)各构成组分的相关性,了解Lep在老年MS发生、发展中的作用。方法:入选符合国际糖尿病联盟(IDF)2005年MS诊断标准的老年MS患者76例。选与研究组年龄相匹配的正常对照组20例。通过全自动生化分析仪获取入选者血糖和血脂的指标;对入选者进行身高、体重、腰围及血压的测量;采用双抗体夹心ABC-ELISA法对入选者的血清Lep进行检测;采用BECKMAN ACCESS全自动化学发光仪测定胰岛素水平。结果:老年MS组血清Lep水平明显高于老年对照组[(5.23±2.15)ng/ml vs(2.24±1.95)ng/ml,P<0.01];老年MS肥胖组(BMI≥25kg/m^2)血清Lep水平明显高于MS非肥胖组(BMI<25kg/m^2)[(5.67±2.25)ng/ml vs(4.58±1.85)ng/ml,P<0.05];老年MS患者血清Lep水平与BMI、SBP、FINS、及WC呈显著正相关,与HDL-C、ISI呈显著负相关;随着MS构成组分的增加,Lep及FINS水平显著升高,而ISI显著下降;结论:老年MS患者存在脂肪-胰岛内分泌轴的功能紊乱,老年MS患者同时存在胰岛素抵抗和Lep抵抗;高血压、肥胖及HDL-C下降在老年MS中占有重要地位,应强调对老年人进行生活方式的干预并促进血压、血脂的达标。 Objective: In order to further understand the role of leptin on the developing and progressing of MS in elderly people, we carry out the study analysing the relationship between leptin and the individual components of MS. Methods: According to IDF 2005 criteria of MS, we enrolled 76 elderly patients with MS and 20 elderly people matched in age without MS. We obtained anthropometric parameters ( weight, height, waist circumference ) and biochemical parameters (lipid profiles, fasting plasma glucose levels ) respoctively, applied ABC - ELISA technology to detect serum leptin levels and tested the fasting insulin levels with Beckman Access instrument. Results: The serum leptin levels of 76 elderly patients with MS and control group were (5.23 ± 2.15 )ng/ml vs (2.24 ± 1.95 ) ng/ml, P 〈 0.01. There was also statistic significant difference in leptin levels between obesity (BMI ≥ 25kg/m^2) group and non - obesity (BMI 〈 25kg/m^2) group with MS. Correlation analysis demonstrated that leptin levels with MS were positively related to BMI,SBP, FINS and WC, but negatively related to HDL- C and ISI. The mare components of MS in one person, the higher levels of leptin and FINS as well as the lower levels of ISI in his blood would be found. Conclusion: There exists the dysfunction of leptin - insulin axis in elderly people with MS and also exists leptin resistance as well as insulin resistance. Hypertension, obesity and low HDL- C play an important role in MS of the elderly people. The intervention of MS in the elderly patients should focus on lifestyle modification: losing weight especially targeting on the central obesity and treating to target of blood pressure.
出处 《中国医药导刊》 2007年第3期203-205,共3页 Chinese Journal of Medicinal Guide
关键词 老年代谢综合征 瘦素 Metabolic Syndrome in Elderly Leptin
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