摘要
目的探讨养血清脑颗粒对偏头痛患者溶血磷脂酸(LPA)、肿瘤坏死因子(TNF)水平的影响。方法治疗组:160例,采用盐酸氟桂利嗪胶囊加养血清脑颗粒治疗;对照组:58例,单独使用盐酸氟桂利嗪胶囊;健康组:35例。均采用酶免法及严格按试剂说明书操作,对3组受检者外周血LPA、TNF水平进行了检测。结果治疗组偏头痛患者外周血LPA及TNF水平在用药24h前和用药2周均较健康组高(P<0.01),用药4周基本恢复健康组水平(P>0.05);治疗组在用药2周、4周LPA、TNF水平均较对照组低(P<0.05)。而对照组在用药的2周、4周均较健康组高(P<0.01,P<0.05)。结论采用盐酸氟桂利嗪胶囊加养血清脑颗粒较单独使用盐酸氟桂利嗪胶囊治疗能更显著的降低偏头痛患者外周血LPA及TNF水平,并能更快更好的缓解头痛症状。提示LPA、TNF增高在偏头痛发作期的发病中发挥一定作用,养血清脑颗粒可有效降低偏头痛发作时LPA、TNF水平和缓解头痛症状。
Objective To explore the effect of Yangxueqingnao Granula on LPA and TNF level in patients with migraine. Methods Study group （160 cases） were given flunarizine hydrochloride capsules and Yangxueqingnao Granula. Control group （58 cases） were given only flunarizine hydrochloride capsules. 35 cases of healthy people composed health group. The serum level of LPA and TNF of three group was detected by enzyme--immunoassay method which was implemented strictly according to specification. Results The serum level of LPA and TNF of patients with migraine was higher than health group in 24 hours before and 2 weeks after drug therapy, then decreased to the level of health group at the fourth week. The serum levels of LPA and TNF of control group were higher than study group or health group at the second and fourth week after drug therapy. Conclusion The combined application of flunarizine hydrochloride capsules and Yangxueqingnao Granula can make the serum level of LPA and TNF lower than use of only flunarizine hydrochloride capsules and make better headache relief. The study indicates that the increase of LPA and TNF level has effect to some extent on the occurrence of migraine and Yangxueqingnao Granula can make the serum level of LPA and TNF decrease effectively to relieve headache.
出处
《中国实用神经疾病杂志》
2009年第1期32-35,共4页
Chinese Journal of Practical Nervous Diseases
