摘要
目的探讨转化生长因子-β1(TGF-β1)、基质金属蛋白酶-2(MMP-2)在宫颈腺癌组织中的表达及临床意义。方法收集39例宫颈腺癌患者的癌组织标本和20例行子宫肌瘤切除术患者的宫颈腺上皮组织标本,采用免疫组化SP法检测各组织中的TGF-β1、MMP-2表达,分析二者表达与宫颈腺癌患者临床病理参数的关系。结果与正常宫颈上皮组织比较,TGF-β1、MMP-2在宫颈腺癌组织中的阳性表达率明显升高(P均<0.05)。TGF-β1、MMP-2表达与宫颈腺癌患者的年龄、肿瘤大小、分化程度及淋巴结转移无关,与临床分期有关(P<0.05),且二者表达具有正相关性(P<0.05)。结论 TGF-β1、MMP-2可能与宫颈腺癌的发生、发展有关,可作为判断患者预后的指标之一。
Objective To investigate the expression and clinical significance of transforming growth factor-β1 （TGF-β1）and matrix metalloproteinase 2 （MMP-2） in the tissues of cervical adenocarcinoma.Methods The expression of TGF-β1 and MMP-2 in 39 cases of patients with cervical carcinoma and 20 cases of normal cervical epithelium in patients undergoing hysteromyomectomy was detected by immunohistochemistry technology （SP＇s approach）,and the relation with clinical pathological parameters of cervical adenocarcinoma was analyzed.Results The positive expression rate of TGF-β1 and MMP-2 in cervical adenocarcinoma was significantly increased as compared with that of normal cervical epithelial tissues （all P ＜ 0.05） ;the expression of TGF-β1 and MMP-2 in cervical adenocarcinoma was not associated with some clinical features such as age,tumor size,degree of differentiation,lymph node metastasis （P ＞ 0.05）,but associated with clinical stages （P ＜ 0.05）,and meanwhile,the expression of TGF-β1 was positively correlated with the expression of MMP-2 （P ＜ 0.05）.Conclusions TGF-β1 and MMP-2 are associated with the occurrence and development of cervical adenocarcinoma.TGF-β1 and MMP-2 can be used as the useful molecular markers for prognosis of cervical adenocarcinoma.
出处
《山东医药》
CAS
2014年第5期15-17,共3页
Shandong Medical Journal
基金
四川省教育厅科研基金项目(09ZA178)
关键词
宫颈腺癌
转化生长因子-Β
基质金属蛋白酶-2
免疫组化方法
cervical adenocarcinoma
transforming growth factor-β1
matrix metalloproteinase 2
immunohistochemistry
