摘要
目的研究Smad2蛋白在正常宫颈、宫颈上皮内瘤变与宫颈浸润癌中的表达,及与临床病理学特征的关系。方法选择宫颈上皮瘤变组织样本67例(CIN组),宫颈浸润癌组织样本53例(ICC组),正常宫颈组织样本30例(NCE组),采用免疫组化SP法检测各组织中Smad2蛋白的表达。结果正常宫颈、宫颈上皮内瘤变与宫颈浸润癌组织中Smad2阳性率、染色程度得分、阳性细胞占比得分及表达强度比较,差异均有统计学意义(P<0.01)。CIN1级、CIN2级、CIN3级Smad2阳性率和表达强度得分比较,差异有统计学意义(P<0.01),表达强度得分与宫颈上皮内瘤变分级呈负相关(P<0.05)。Smad2在宫颈浸润癌组阳性表达与病理分级有关(P<0.05)。结论Smad2蛋白在宫颈浸润癌组织中的表达低于正常宫颈组织和宫颈上皮内瘤变组织,Smad2蛋白与宫颈上皮内瘤变病变程度有关,且与宫颈浸润癌恶性程度有关。Smad2蛋白低表达可能在宫颈癌前病变进展及宫颈癌发生发展中起重要作用。
Objective To study the Smad2 protein in normal cervix, cervical intraepithelial neoplasia and cervical in- vasive carcinoma, and the relationship with clinicopathologieal features. Methods Cervical intraepithelial neoplasia tissue sample 67 cases(CIN group), 53 cases of invasive cervical cancer tissue samples (ICC group), 30 cases of nor- mal cervical tissue samples (NCE group), used immunohistochemical SP method to detect the organization of Smad2 protein. Results In normal cervix, cervical intraepithelial neoplasia and cervical carcinoma tissues Smad2 positive rate, the degree of staining score, score and percentage of positive cells express strength, the difference was statisti- cally significant (P〈0.01). CIN1, CIN2, CIN3 grade Smad2 positive rate and expression intensity score, the difference were statistically significant (P〈0.01), the expression intensity score with cervical intraepithelial neoplasia grade were negatively correlated (P〈0.05). Smad2 expression in cervical carcinoma were related to degree of differentiation, pathological grade (P〈0.05). Conclusion Smad2 protein in cervical carcinoma tissues than normal cervical tissue and cervical intraepithelial neoplasia tissue, Smad2 protein and cervical intraepithelial neoplasia lesions related to the de- gree, and with the degree of differentiation of invasive cervical cancer and pathology grading. Smad2 protein expres- sion may be low in cervical precancerous cervical lesions progress and play an important role in the occurrence and development.
出处
《中国现代医生》
2013年第29期69-71,共3页
China Modern Doctor
基金
国家自然科学基金(30973425)
关键词
宫颈癌
浸润癌
宫颈上皮内瘤变
SMAD2
Cervical cancer
lnvasive carcinoma
Cervical intraepithelial neoplasia
Smad2