摘要
目的探讨嗜酸性粒细胞趋化因子eotaxin在鼻息肉患者鼻腔分泌物中的表达及意义。方法共选取40例患者鼻腔分泌物,其中15例为鼻息肉患者,15例为慢性鼻窦炎患者,10例为单纯鼻中隔偏曲患者。使用酶联免疫吸附法(ELISA)检测eotaxin的浓度。结果鼻息肉患者鼻腔分泌物eotaxin的平均浓度为(468.82±440.64)pg/mL,慢性鼻窦炎患者鼻腔分泌物eotaxin的平均浓度为(443.85±334.68)pg/mL,单纯鼻中隔偏曲患者eotaxin的平均浓度为(149.23±49.01)pg/mL。鼻息肉、慢性鼻窦炎患者鼻腔分泌物eotaxin浓度均高于鼻中隔偏曲患者鼻腔分泌物eotaxin浓度,差异有统计学意义(P<0.05)。结论eotaxin浓度在鼻息肉患者鼻腔分泌物中明显升高,可以认为eotaxin在鼻息肉疾病发病、发展中起了重要的作用。
Objective To discuss the expression and significance of eotaxin in the nasal secretions of the patients with nasal pol-yps .Methods The nasal secretion samples were collected from 40 patients including 15 cases of nasal polyps ,15 cases of chronic si-nusitis and 10 cases of nasal septum deviation .The enzyme-linked immunosorbent assay（ELISA） was adopted to detect the concen-tration of eotaxin .Results The average concentration of eotaxin was （468 .82 ± 440 .64）pg/mL in nasal polyps ,（443 .85 ± 334 .68） pg/mL in chronic sinusitis and （149 .23 ± 49 .01）pg/mL in nasal septum deviation .The eotaxin concentrations in the nasal polyps group and the chronic sinusitis group were higher than those in the nasal septum deviation group ,the difference was statistically significant（P＆lt;0 .05） .Conclusion The eotaxin concentration in the nasal secretions of the patients with nasal polyps is significantly increaseed ,which might be concluded that eotaxin may play an important role in the occurrence and development process of nasal polyps .
出处
《重庆医学》
CAS
CSCD
北大核心
2014年第3期288-289,292,共3页
Chongqing medicine
