摘要
长期以来,人们对于T淋巴细胞的研究集中在辅助性T细胞1型、2型（Th1、Th2）、调节性T细胞（Treg）以及细胞毒性T细胞（Tc）等亚群上。传统理论认为,Th1细胞介导细胞免疫,在抗胞内菌感染的过程中发挥作用;而Th2细胞介导体液免疫,与过敏性疾病以及抗寄生虫感染的过程紧密相关。Th1/Th2失衡被认为是许多疾病产生和发展的重要因素。
The idea has been popular for a long time that Th1/Th2 imbalance is the major cause of many diseases. However,the Th1/Th2 paradigm has encountered increasing challenge since the discovery of a novel subset of Th cells,Th17.Th17 cells secrete a series of cytokines（IL-17A ~ F,IL -21 and IL -22）,which is quite different from those produced by Thl and Th2 cells.It is now generally accepted that Th17/IL-17A plays a pivotal role in autoimmune and host defense.Although first discovered in autoimmune diseases,emerging studies begin to explore the way in which Th17/IL-17A acts in chronic inflammatory airway diseases,such as asthma and chronic obstructive pulmanary disease.In this review,we will summarize the differentiation and function of Th17,and introduce the progress in the correlation between Th17/IL-17A and chronic inflammatory airway diseases.Further elucidating the mechanism of Th17/IL-17A-related pathophysiological changes will contribute to prevention and treatment of chronic inflammatory airway diseases.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2012年第3期560-564,共5页
Chinese Journal of Pathophysiology
基金
国家重点基础研究发展计划(973计划)(No.2009CB522103)
