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非编码RNA与慢性阻塞性肺疾病

Non-coding RNAs and Chronic obstructive pulmonary disease
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摘要 非编码RNA即不能编码蛋白质的RNA,主要包括微小RNA以及长链非编码RNA,在细菌、真菌、哺乳动物等许多生物体的生命活动中发挥着极广泛的调控作用.目前越来越多的临床研究者开始关注非编码RNA的生物学功能及与机体各个系统疾病的关系,人们逐渐意识到,非编码RNA的研究对了解人类疾病防治及生物进化探索等都具有重要意义. Non-coding RNAs that can not encoding RNA protein,mainly include microRNAs and long non-coding RNAs,in bacteria,fungi,mammals,and many other biological activities life play a very wide range of regulatory role.More and more clinical researchers have begun to pay attention to the biological function of the non-coding RNAs and the relationship between the various diseases of the body,and people gradually realized that the study of non-coding RNAs has important significance for understanding human disease control and biological evolution.
出处 《中国医师杂志》 CAS 2016年第3期477-480,共4页 Journal of Chinese Physician
关键词 微RNAs/代谢 RNA/代谢 肺疾病 慢性阻塞性/代谢 综述 MicroRNAs/ME RNA/ME Pulmonary disease,chronic obstructive/ME Review
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参考文献29

  • 1路明,姚婉贞.慢性阻塞性肺疾病防治全球倡议(2015年更新版)解读[J].中华医学杂志,2015,95(22):1715-1718. 被引量:42
  • 2唐剑,陶晓南.免疫反应在慢性阻塞性肺疾病发病机制中的研究现状[J].中国医师杂志,2014,16(11):1458-1463. 被引量:4
  • 3Wang M, Huang Y, Liang Z, et al. Plasma miRNAs might be promising biomarkers of chronic obstructive pulmonary disease [J]. Clin Respir J, 2016,10(1):104-111. DOI: 10. llll/crj. 12194. 被引量:1
  • 4Consortium EP, Bemstein BE, Bimey E, et al. An integrated en- cyclopedia of DNA elements in the human genome [ J ] Nature, 2012, 489(7414) :57-74. DOI: 10. 1038/naturel1247. 被引量:1
  • 5Ebrahirni A, Sadroddiny E. MieroRNAs in lung diseases: Recent findings and their pathophysiologieal implications[ J]. Pulm Phar- maeol Ther, 2015,34:55-63. DOI: 10. 1016/j. pupt. 2015.08. 007. 被引量:1
  • 6杨峰,易凡,曹慧青,梁子才,杜权.长链非编码RNA研究进展[J].遗传,2014,36(5):456-468. 被引量:69
  • 7Takahashi K, Yokota S, Tatsumi N, et al. Cigarette smoking sub- stantially alters plasma microRNA profiles in healthy subjects[J]. Toxicol Appl Pharmacol, 2013,272 ( 1 ) : 154-160. DOI: 10. 1016/j. taap. 2013.05. 018. 被引量:1
  • 8Graft JW, Powers LS, Dickson AM, et al. Cigarette smoking de-creases global micmRNA expression in human alveolar macropha- ges[J]. PLoS 0ne,2012,7(8) :e44066. DOI: 10. 1371/journal. pone. 0044066. 被引量:1
  • 9Izzotti A, Calin GA, Arrigo P, et al. Downregulation of mieroRNA expression in the lungs of rats exposed to cigarette smoke [ J ]. FASEB J, 2009,23(3) :806-812. DOI: 10. 1096/t].08-121384. 被引量:1
  • 10Schembri F, Sridhar S, Perdomo C, et al. MicroRNAs as modula- tors of smoking-induced gene expression changes in human airway epithelium[J]. Pmc Natl Acad Sci USA, 2009, 106(7):2319- 2324. DOI: 10. 1073/pnas. 0806383106. 被引量:1

二级参考文献85

  • 1Decramer M, Janssens W, Miraviflles M. Chronic obstructive pul- monary disease[ J]. The Lancet,2012,379(9823 ) : 1341-1351. 被引量:1
  • 2Vestbo J, Hurd SS, Agusti AG, et al. Global strategy for the diag- nosis, management, and prevention of chronic obstructive pulmo- nary disease: GOLD executive summary [ J ]. Am J Respir Crit Care Med,2013,187(4) :347-365. 被引量:1
  • 3Shaykhiev R, Otaki F, Bonsu P, et al. Cigarette smoking repro- grams apical junctional complex molecular architecture in the hu- man airway epithelium in vivo [ J ]. Cell Mol Life Sci, 2011,68 i (5) :877-892. 被引量:1
  • 4Leopold PL, O'Mahony MJ, Lian XJ, et al. Smoking is associated with shortened airway cilia[J]. PLoS One,2009,4(12) : e8157. 被引量:1
  • 5Tamashiro E, Xiong G, Anselmo-Lima WT, et al. Cigarette smoke exposure impairs respiratory epithelial ciliogenesis [ J ]. Am J Rhi- nol Allergy,2009,23 (2) : 117-122. 被引量:1
  • 6Yu H, Li Q, Kolosov VP, et al. Regulation of cigarette smoke-me-diated mucin expression by hypoxia-inducible factor-1 ct via epider- mal growth factor receptor-mediated signaling pathways [ J ]. J Appl Toxicol,2012,32(4) :282-292. 被引量:1
  • 7Sajjan US. Susceptibility to viral infections in chronic obstructive pulmonary disease: role of epithelial cells [ J ]. Curr Opin Pulm Med ,2013,19 (2) : 125-132. 被引量:1
  • 8Pappas K, Papaioannou AI, Kostikas K, et al. The role of macro- phages in obstructive airways disease: Chronic obstructive pulmo- nary disease and asthma[ J ]. Cytokine ,2013,64 (3) :613-625. 被引量:1
  • 9Shaykhiev R, Krause A, Salit J, et al. Smoking-dependent repro- gramming of alveolar macrophage polarization: implication for pathogenesis of chronic obstructive pulmonary disease [ J ]. J Immu- no1,2009,183 (4) :2867-2883. 被引量:1
  • 10Metcalfe HJ, Lea S, Hughes D, et al. Effects of cigarette smoke on Toll-like receptor (TLR) activation of chronic obstructive pul- monary disease ( COPD ) macrophages [ J ]. Clin Exp Immunol, 2014,176(3) :461-472. 被引量:1

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