摘要
目的探讨补肾健脾中药方对去卵巢大鼠血清SOD和MDA的影响。方法 48只6月龄的雌性SD大鼠随机分为正常空白组、模型组、中药组、西药组。治疗12周后,收集左侧股骨、血清分别行BMD测量和SOD、MDA检测。结果最后纳入研究动物40只。股骨BMD值:模型组低于正常空白组(P<0.01);观察组、对照组分别与模型组比较,差异有统计学意义(P<0.05)。在SOD方面,观察组、对照组的SOD值均比模型组高,三者比较,有统计学意义(P<0.05)。在MDA方面,观察组、对照组的MDA值均比模型组低,三者比较,有统计学意义(P<0.05)。结论补肾健脾中药康方具有提高去卵巢大鼠BMD的作用;能够提高血清中SOD的含量,同时减低MDA含量,在一定的程度上清理自由基,达到防治骨质疏松症的目的。
Objective To investigate the effect of the tonifying the kidney and strengthening the spleen prescription on serum super oxide dismutase （ SOD） and malondialdehyde （ MDA） in ovariectomized rats.Methods Forty-eight 6-month female SD rats were randomly divided into 4 groups （ n=12 ）： normal group, ovariectomized group, control group, and observation group. After 12-week treatment, bone mineral density （ BMD） of the left femur was detected, and the serum levels of SOD and MDA were also detected.Results Forty rats were included in the study finally.BMD of the femur in normal group was higher than that in ovariectomized group （P＆lt;0.01）.Significant difference of BMD of the femur in observation group and control group was observed compared with that in ovariectomized group （ P ＆lt;0.05 ） , respectively.The serum level of SOD in both observation group and control group was higher than that in ovariectomized group, and significant difference was observed among 3 groups （P＆lt;0.05）. On the contrary, the serum level of MDA in both observation group and control group was lower than that in ovariectomized group, and significant difference was also observed among 3 groups （P＆lt;0.05）.Conclusion The tonifying the kidney and strengthening the spleen prescription can improve BMD in ovariectomized rats, improve the serum level of SOD, and reduce the serum level of MDA, which can clear up free radicals to some extent, achieving the purpose of preventing and treating osteoporosis.
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2014年第1期1-4,共4页
Chinese Journal of Osteoporosis
基金
国家自然科学基金(81001532)
广东省自然科学基金(S2011010005671)
广东省科技计划项目(2009B03081301)
关键词
去卵巢大鼠
中药复方
超氧化物歧化酶
丙二醛
Ovariectomized rats
Chinese herbal compound
Super oxide dismutase
Malondialdehyde
