摘要
目的探讨依达拉奉对体外循环下冠状动脉搭桥术患者血浆S100-B蛋白水平的影响及其机制。方法选择行体外循环下冠状动脉搭桥术患者30例，随机分为实验组15例和对照组15例。实验组依达拉奉0．5mg,／kg于麻醉诱导后5min静脉滴注及O．5mg／kg于主动脉开放前5min加入体外循环机内；对照组不用依达拉奉。两组分别于麻醉诱导后5rain（T1）、主动脉开放后5rain（T2）及手术结束后1h（T3）、2h（T4）、6h（T5）、24h（T6）采集患者颈内静脉血，检测血清S100-B蛋白水平。结果两组S100-B蛋白在他～T5时间段高于T1（P〈0．01），实验组S100-B蛋白浓度在亿-T5时间段低于对照组（P〈0．05或0．01）。结论依达拉奉可减轻体外循环下冠状动脉搭桥术患者的脑损伤，其机制可能与其通过血脑屏障，有效清除自由基和抑制脂质过氧化的作用，抑制脑细胞的过氧化作用，减轻脑缺血和脑缺血引起的脑水肿有关。
Objective To investigate the effect of edaravone on the serum S100-B protein levels in patients with off-pump coronary artery bypass surgery and its mechanism. Methods Thirty patients treated by off-pump coronary artery bypass graft surgery were randomly divided into experimental group （n = 15）and control group （n = 15）. Patients in experimental group were given edaravone 0.5 mg/ kg at 5 min after induction of anesthesia, intravenous infusion and another 0.5 mg / kg added into cardiop- ulmonary bypass machine at 5 min before aortic opening; Patients in control group were not given edara- vone. Jugular venous blood were collected and the serum levels of edaravone were detected at 5 min after induction of anesthesia（ T1 ）, 5 min after the opening of aorta （ T2）, 1 h （ T3 ）, 2 h （ T4 ）, 6 h （ 3＂5 ） and 24 h （T6） after surgery. Results The serum levels of S100-B at T2 ~3＇5 were higher than those in T1 time period（P 〈0.01 ） ; The serum levels of S100-B in experimental group at T2 - T5 were lower than those in control group （P 〈 0.05 or 0.01 ）. Conclusions Edaravone can reduce the brain injury of patients with coronary artery bypass surgery under cardiopulmonary bypass （CPB）, its mechanism may be related to through blood-brain barrier, effectively scavenge free radicals and inhibit lipid peroxidation, inhibition of brain cells over oxidation, reduce cerebral ischemia and cerebral ischemia-induced brain edema.
出处
《中国实用医刊》
2014年第4期25-26,共2页
Chinese Journal of Practical Medicine
