摘要
目的 分析侵袭性NK细胞白血病的临床特征及诊治方法,探讨流式细胞术（FCM）对其诊断的价值.方法 分析1例侵袭性NK细胞白血病患者的临床特征,并进行文献复习.结果 患者持续高热、肝脾进行性增大、血三系细胞减少,骨髓中可见不典型细胞,FCM检查示骨髓中NK细胞约占淋巴细胞的83.3％,免疫表型为CD34-、CD2＋、CD7＋、CD3-、CyCD3＋、CD5-、CD16＋、CD56＋、CD30-、CD4-、CD8-、CD117-、CD11c-、CD19、CD45＋＋、SSC＋-＋＋,TCR、IgH基因重排阴性,染色体正常,诊断为侵袭性NK细胞白血病.结论 侵袭性NK细胞白血病是一种少见的血液系统恶性疾病,临床表现多样、疾病进展迅速,早期容易误诊,FCM免疫分型结合骨髓细胞学涂片具有简便、快捷、可行、创伤性小的优势,在一些特殊情况下可作为首选检测手段.
Objective To explore clinical characteristics and diagnosis of aggressive natural killercell leukemia （ANKL）,and evaluate the value of flow cytometry （FCM） in diagnosing it.Methods A case of ANKL was reported and literatures were reviewed.Results The patient presented with persistent high fever,progressive pancytopenia and hepatosplenomegaly.The untypical cells could be seen by morphology.By FCM,NK cells consisted 83.3 ％ of total lymphocytes in bone marrow and immunophenotypes were CD34-,CD2＋,CD7＋,CD3-,CyCD3＋,CD5-,CD16＋,CD56＋,CD30-,CD4-,CD8-,CD117-,CD11c,CD19-,CD45＋＋,SSC＋-＋＋.T-cell receptor （TCR） and IgH gene rearrangement were negative and chromosome was normal.The patient was diagonised ANKL eventually.Conclusions ANKL is a quite rare disease with highly aggressive,poor prognosis and could be misdiagnosed easily.FCM combined with morphology is a convenient,handy,practicable and less invasive device for the diagnosis,and can be a preferred detection technique in some cases.
出处
《白血病．淋巴瘤》
CAS
2014年第1期38-40,44,共4页
Journal of Leukemia & Lymphoma
