摘要
目的 :观察升压灵注射液清除氧自由基能力和抗脂质过氧化作用。方法 :采用体外氧自由基生成系统和FRGS诱导的小鼠心肌组织匀浆脂质过氧化反应 ,评价升压灵注射液抗氧化作用。结果 :升压灵注射液可消除次黄嘌呤—黄嘌呤氧化酶系统所产生的O- ·2 和Fenton反应生成的·OH ,并能抑制FRGS诱导的小鼠心肌组织匀浆脂质过氧化作用。结论 :升压灵注射液具有抗氧化能力。
Objective: To observe oxygen-free-radical clearing activity and anti-lipid peroxidation of Shengyaling injection in vitro. Method: In-vitro oxygen free radical generation system (OFRGS) and lipid peroxidation induced by OFRGS in the supernatant fluid of mice heart tissue homogenate were used to evaluate the anti-oxidation activity of Shengyaling injection. Result:Shengyaling injection cleared superoxidase anion free radical induced by hypoxanthine-xanthine oxidase system and hydroxyl free radical induced by fenton reaction system, and inhibited mice heart tissue lipid peroxidation induced by FRGS at a dose-dependent manner. Conclusion:Shengyaling injection possesses an anti-oxidation effect.
出处
《中药新药与临床药理》
CAS
CSCD
2001年第1期24-26,共3页
Traditional Chinese Drug Research and Clinical Pharmacology
基金
国家"八五"科技攻关项目! (85 - 92 0 - 0 4- 0 3B)
