期刊文献+

脓毒症患儿高血糖的研究进展 被引量:12

Hyperglycemia in children with sepsis
原文传递
导出
摘要 脓毒症在儿科疾病中十分常见,严重者易发生多器官功能损伤,使患儿死亡风险增高.高血糖是脓毒症后体内代谢紊乱的重要标志.脓毒症可引起胰腺损伤,并非所有的高血糖都是一过性的、应激状态的表现,降低脓毒症患儿的高血糖有助于降低脓毒症患儿的并发症发生和病死率.该文对脓毒症患儿血糖紊乱的发生、调控及预后予以探讨. Sepsis is one of common diseases in pediatrics,critically ill children tend to suffer multiple organ damage that will increase children's risk of death.Hyperglycemia is an important symbol of metabolic disorder after onset of sepsis,with the deepening of understanding that sepsis can cause the pancreatic damage.Therefore,not all hyperglycemia is a representation of transient or stress state.To control hyperglycemia of sepsis in children can help to reduce their complications and mortality.In this review,it will deal with the occurrence of sepsis in children with blood glucose disturbance,regulation and prognosis.
出处 《中国小儿急救医学》 CAS 2014年第2期115-118,共4页 Chinese Pediatric Emergency Medicine
关键词 脓毒症 高血糖 胰腺损害 胰岛素 儿童 Sepsis Hyperglycemia Pancreatic damage Insulin Children
  • 相关文献

参考文献36

  • 1Wintergerst KA, Buckingham B, Gandrud L, et al. Association of hypoglycemia, hyperglycemia, and glucose variability with morbidity and death in the pediatric intensive care unit [ J ]. Pediatrics,2006,118( 1 ) : 173-179. 被引量:1
  • 2Hardt PD,Mayer K, Ewald N. Exocrine pancreatic involvementin critically ill patients [ J ]. CUlT Opin Clin Nutr Metab Care, 2009,12 (2) :168-174. 被引量:1
  • 3Preissig CM, Rigby MR. Pediatric critical illness hyperglycemia: risk factors associated with development and severity of hyper- glycemia in critically ill children [ J ]. J Pediatr, 2009,155 ( 5 ) : 734-739. 被引量:1
  • 4Solomon SS, Buss N, Shull J, et al. Proteome of H-411E (liver) cells exposed to insulin and tumor necrosis factor-alpha:analysis of proteins involved in insulin resistance [ J ]. J Lab Clin Med, 2005,145 (5) :275-283. 被引量:1
  • 5Maedler K,Sergeev P, Ris F, et al. Glucose-induced beta cell production of IL-lbeta contributes to glucotoxicity in human pancreatic islets[ J]. J Clin Invest,2002,110 ( 6 ) : 851-860. 被引量:1
  • 6Elrick LJ, Docherty K. Phosphorylation-dependent nucleocyto- plasmic shuttling of pancreatic duodenal homeobox-1[ J]. Dia- betes,2001,50(10) :2244-2252. 被引量:1
  • 7Seufert J, Kieffer TJ,Leech CA, et al. Leptin suppression of in- sulin secretion and gene expression in human pancreatic islets: implications for the development of adipogenic diabetes mellitus [ J]. J Clin Endocrinol Metab, 1999,84 (2) :670-676. 被引量:1
  • 8Maedler K,Sergeev P, Ehses JA, et al. Leptin modulates beta cell expression of IL-1 receptor antagonist and release of IL-1 beta in human islets[J]. Proc Natl Acad Sci U S A,2004,101 (21) :8138-8143. 被引量:1
  • 9Robinson LE, van Soeren MH. Insulin resistance and hypergly- cemia in critical illness:role of insulin in glycemic control [ J ]. AACN Clin Issues ,2004,15 ( 1 ) :45-62. 被引量:1
  • 10Marik PE, Raghavan M. Stress-hyperglycemia, insulin and im- munomodulation in sepsis[ J ]. Intensive Care Med, 2004, 30 (5) :748-756. 被引量:1

二级参考文献25

共引文献45

同被引文献128

引证文献12

二级引证文献46

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部