摘要
目的 评价混合痔吻合器痔上黏膜环切术（PPH）后应用重组人酸性成纤维细胞生长因子（rh-aFGF）对伤口愈合及远期瘢痕的影响.方法 采用前瞻性、随机数列表、分配隐藏等临床试验设计方法选择2012年6月～2013年2月河北省三个研究医院混合痔患者104例为研究对象,随机分为试验组和对照组,每组各52例.两组均给予PPH套扎技术,试验组给予20 mL外用冻干rh-aFGF冲洗,对照组给予太宁栓治疗.评价两组患者的住院时间、症状体征评分、恢复工作时间,并观察患者的瘢痕形成、肛门狭窄、肛门失禁指数及复发情况.结果 试验组完全愈合时间、恢复工作的时间及住院时间[（9.58±1.56）、（11.48±0.59）、（3.740.44）d]明显少于对照组[（7.42±1.42）、（15.41±0.38）、（4.67±0.45）d],差异均有统计学意义（均P＜0.05）.试验组延迟愈合发生率（1.9％）明显低于对照组（13.4％）,甲级愈合率（96.1％）明显高于对照组（84.6％）,两组相比,差异有统计学意义（P＜ 0.05）.试验组瘢痕形成率及肛门狭窄率（17.3％、1.9％）均低于对照组（38.4％、11.5％）,两组相比,差异有统计学意义（P＜0.05）.结论 rhaFGF仅能缩短PPH后伤口愈合时间,减少远期瘢痕形成及肛门狭窄,对患者复发无明显影响.
Objective To study the efficacy of recombinant human acidic fibroblast growth factor （rh-aFGF） in promot- ing wound healing of mixed hemorrhoid after procedure for prolapse and hemorrhoids （PPH）. Methods The multiple center, randomized controlled was conducted, 104 patients were randomly divided into the experimental group and con- trol group, with 52 cases in each group. Both groups were treated with PPH, the patients of experimental group were treated with 20 mL external use rh-aFGF in addition, and the patients of control group were treated with Titanoreine Suppositor in addition. The hospital stays, signs and symptoms score and the time of return to work in two groups were evaluated, the scarring formation, anal stenosis, anal incontinence index and relapse were observed. Results The time of healing, return to work, and hospital in experimental group [（9.58±1.56）, （11.48±0.59）, （3.74±0.44） d] were less than those of control group[（7.42±l.42）, （15.41±0.38）, （4.67±0.45） d], the differences were statistically significant （P 〈 0.05）. The delayed union rate of experimental group （1.9%） was low than that of control group （13.4%）, but class A healing rate of experimental group （96.1%） was higher than that of control group （84.6%）, the differences of two groups were statisti cally significant （all P 〈 0.05）. The rate of scar formation and anal stenosis of experimental group （17.3%, 1.9%） was low than those of control group （38.4%, 11.5%）, the difference was statistically significant （P 〈 0.05）. Conclusion rh aFGF can short the time time of healing after PPH, and decrease the scarring formation and anal stenosis in future, has no obvious effect on relapse.
出处
《中国医药导报》
CAS
2014年第5期56-59,共4页
China Medical Herald
关键词
重组人酸性成纤维细胞生长因子
混合痔
愈合
复发
Recombinant human acidic fibroblast growth factor
Mixed hemorrhoid
Heallingtime
Relapse
