摘要
采用葡萄糖和2,4-戊二酮经Knoevenagel缩合反应制备得到β-丙酮基葡萄糖,β-丙酮基葡萄糖与苯环取代的邻氨基苯甲醛经Friedlnder缩合反应,以高达90%的产率合成了4个结构新颖的葡萄糖基喹啉类化合物.目标化合物的结构均经1HNMR,13CNMR和元素分析确证。
Knoevenagel condensation of pentane-2,4-dione with different unprotected glucose in alkaline aqueous media gave quantitatively in one step β-C-glycosidic ketones. Friedlnder condensation reaction of β-C-glycosidic ketones with substituted o-aminobenzaldehyde gave four novel C-2-β-D-Glucoside quinoline derivatives in high yield（ up to 90%）. The four β-C-glycosidic quinolines were identified by1H NMR,13C NMR spectra and elemental analysis.
出处
《广州化工》
CAS
2014年第1期6-8,共3页
GuangZhou Chemical Industry
基金
国家自然科学基金项目(No:20808021)
