摘要
目的 了解2型糖尿病（T2DM）患者空腹血糖（FPG）水平与胰岛α及β细胞功能的相关性.方法 选择437例T2DM患者,按空腹血糖（FPG）水平分为三组：F1组：FPG≤6 mmol/L （73例）,F2组：6 mmol/L＜ FPG≤7 mmol/L（103例）,F3组：FPG＞7mmol/L（261例）,选择同期健康体检者30例作为对照组.联合进行口服葡萄糖耐量试验及胰岛素、胰高血糖素释放试验,比较各组间胰高血糖素、胰高血糖素/胰岛素、糖负荷后30 min胰岛素和血糖净增值的比值（△I30/△G30）、胰岛素曲线下面积（AUC1）等的变化,并对胰高血糖素与胰岛β细胞功能、糖化血红蛋白（HbA1c）等指标行相关性分析.结果 T2DM各组HbA1c、糖负荷后120 min血糖均明显高于对照组,差异有统计学意义（P＜0.05）.T2DM各组随着FPG的升高HbA1c、病程、糖负荷后120 min血糖呈现升高的趋势.F2组、F3组三酰甘油高于F1组、对照组,F3组低密度脂蛋白胆固醇高于F1组、F2组、对照组,差异有统计学意义（P＜0.05）.F1组糖负荷后60,120 min时,F2组糖负荷后30,60,120 min时,F3组糖负荷后30,60,120,180 min时胰高血糖素均高于对照组同时间点,差异有统计学意义（P＜0.05）.F2组糖负荷后60,120,180 min时,F3组空腹及糖负荷后30,60,120,180 min时胰高血糖素均高于F1组同时间点,差异有统计学意义（P＜0.05）.F3组空腹及糖负荷后30,60,120,180 min时胰高血糖素均高于F2组同时间点,差异有统计学意义（P＜0.05）.对照组胰高血糖素曲线下面积为9.5±0.3,F1组为9.7±0.2,F2组为9.9±0.2,F3组为10.2±0.3,呈逐渐升高趋势,各组间比较差异均有统计学意义（P＜0.05）.F1组空腹及糖负荷后30,60 min时,F2组空腹及糖负荷后30,60,120 min时,F3组空腹及糖负荷后30,60,120 min时胰高血糖素/胰岛素均高于对照组同时间点,差异有统计学意义（P＜0.05）.F2组空腹及糖负荷后60,120 min时,F3组空腹及糖负荷后30,60,120,180 min时胰高�
Objective To investigate the relationship between fasting plasma glucose （FPG） and islet α-cell and β-cell function in patients with type 2 diabetes mellitus （T2DM）.Methods Four hundred and thirty-seven patients with T2DM were divided into 3 groups according to the level of FPG：F1 group：FPG ≤ 6 mmol/L （73 cases）,F2 group：6 mmol/L ＜ FPG ≤ 7 mmol/L （103 cases）,and F3 group：FPG ＞ 7mmol/L （261 cases）,and 30 cases of healthy people were selected as control group.Oral glucose tolerance test,insulin releasing test and glucagon releasing test were performed to observe the differences of glucagon,glucagon/ insulin,the ratio of 30 min insulin and blood glucose value after glucose load （△ I30/△ G30）,and the area under curve of insulin （AUC1） among the 4 groups and the correlation analysis was performed between glucagon and other indicators.Results Glycosylated hemoglobin （HbA1c）,plasma glucose 120 at min after glucose load in F1,F2 and F3 group were significantly higher than those in control group,and there were statistical differences （P ＜0.05）.In F1,F2,F3 group,with the increase of the HbA1c,the course of disease and plasma glucose at 120 min after glucose load showed increasing trend.The triglyceride in F2 group and F3 group was significantly higher than that in F1 group and control group,and low density lipoprotein cholesterol in F3 group was significantly higher than that in F1 group,F2 group and control group,and there were statistical differences （P ＜ 0.05）.The glucagon at 60,120 min after glucose load in F1 group,30,60,120 min after glucose load in F2 group,and 30,60,120,180 min after glucose load in F3 group was significantly higher than that in control group,and there were statistical differences （P ＜ 0.05）.The glucagon at 60,120,180 min after glucose load in F2 group,at fasting and 30,60,120,180 rain after glucose load in F3 group was significantly higher than that in F1 group,and there were statistical differences （P ＜ 0.05）.The glucag
出处
《中国医师进修杂志》
2014年第4期1-6,共6页
Chinese Journal of Postgraduates of Medicine
基金
国家自然科学基金（81373864）
