摘要
目的探讨宁夏地区2型糖尿病(T2DM)患者抑郁现状分布情况及其与血清尾加压素Ⅱ(UⅡ)、糖化血红蛋白(HbA_(1C))的相关性。方法选取宁夏地区宁夏南、北部山区和银川市城市社区1 208例不同性别、年龄段、文化程度、经济水平的T2DM患者,采用SDS抑郁自评量表对其是否有抑郁状况进行定量评估,研究不同人口学特征T2DM患者的抑郁状况,对不同抑郁状况下的T2DM人群进行有针对性的心理干预。用放射免疫法测定患者血浆中UⅡ的水平,用BioRADD10全自动糖化血红蛋白仪对其血浆HbA_(1C)水平进行测定,对比不同人口学特征T2DM患者体内UⅡ、HbA_(1C)的差异及其与抑郁状况之间的关系。结果女性T2DM患者的抑郁症状标准分值显著高于男性患者(P<0.05),低龄区段T2DM患者的抑郁标准得分显著高于高龄区段(P<0.05),文盲T2DM患者的抑郁标准得分显著高于其他文化程度区段(P<0.05),肥胖T2DM患者抑郁标准分显著高于正常体质量T2DM患者(P<0.05)。女性T2DM患者的血浆UⅡ水平显著高于男性患者(P<0.05),抑郁组血浆UⅡ和HbA_(1C)水平均显著高于非抑郁组(P<0.05)。T2DM患者血浆UⅡ和HbA_(1C)水平与抑郁症之间的相关分析表明,UⅡr=0.41,HbA_(1C)r=0.39(P<0.05)。结论不同人口学特征T2DM患者的抑郁状况分布可能存在较大差异,其抑郁程度与血浆中UⅡ和HbA_(1C)水平可能呈正相关性。
Objective To explore the distribution characteristic of depression disorder of type 2 diabetes patients and its rela- tionship between serum urotensin Ⅱ and HbAlc in Ningxia. Methods SDS self - check list was used to evaluate depression characters of 1208 cases with type 2 diabetes patients varied from gender, age, degree of education and economy level in northern - south district of Ningxia region and urban area, which could effectively evaluate depression status in different population of T2DM. BioRADD10 Automatic Glyco - hemoglobin analyzer was used to determine the HbAlc level in patients and radio immunity method was used to measure the U Ⅱ level, which could be used to compare the different level of U Ⅱ and HbA1c between different population characteristic in T2DM patient. Results The standardized score of depression disorder in female T2DM patients were significantly higher than those in male （P 〈 0.05 ）, the score of the lower - aged patients were also significantly higher than those in the higher - aged patients （ P 〈 0.05 ）, the score of the ilhterate patients were also significantly higher than those in the other - educational patients （ P 〈 0.05 ） ,the score of the fatter pa- tients were also significantly higher than those in the weight - standard level patients （ P 〈 O. 05 ）. The level of the serum U II level was higher in female than those in male （ P 〈 O. 05 ）. The contents of serum urotensin Ⅱ and HbAlc of depression group were significantly higher than those in the non - depression group （ P 〈 0.05 ）. The correlative analysis on the relationship between depression status and that of serum urotensin Ⅱ and HbAlc level showed that the correlative coefficients were 0.41 for urotensin Ⅱ,0.39 for HbAlc （ P 〈 O. 05 ）. Conclusion There are significant difference of the distribution characteristic of depression disorder of T2DM patients in Ningxia,the de- pression status of T2DM patients are positively correlated with the contents of urotensin I/and H
出处
《宁夏医学杂志》
CAS
2015年第12期1092-1095,共4页
Ningxia Medical Journal
基金
宁夏自然科学基金资助项目(NZ14170)
