摘要
目的 通过检测不同糖耐量冠心病（CHD）患者可溶性血管细胞黏附分子（SVCAM-1）、可溶性细胞间黏附分子（SICAM-1）和高敏C-反应蛋白（hs-CRP）水平,观察其相关性,探讨合并糖代谢异常的CHD患者是否存在血管内皮功能障碍和炎症状态.方法 96例CHD患者根据口服葡萄糖耐量试验（OGTT）分成糖代谢正常（NG）组、糖耐量受损（IGT）组和2型糖尿病（T2DM）组,分别检测其与对照组30例患者血清SVCAM-1、SICAM-1和hs-CRP浓度,比较各组间的差异及其相关性.结果 IGT组和T2DM组血清SVCAM-1、SICAM-1、hs-CRP浓度高于其他组,SVCAM-1、SICAM-1与糖化血红蛋白（HbA1c）（r=0.39,0.51,P＜0.01）、hs-CRP（r=0.32,0.56,P＜0.01）均显示出较好的相关性.结论 冠心病患者的血清SVCAM-1、SICAM-1和hs-CRP浓度根据糖耐量水平的分组逐步升高,提示内皮受损、炎症状态可能是CHD合并糖代谢异常患者的重要病理生理因素.
Objective We examined the levels of soluble vascular cell adhesion molecules （SVCAM-1） and soluble intercellular adhesion molecules（SICAM-1 ） and high sensitivity C-reactive protein（hs-CRP） in coronary heart desease （CHD） patients with different glucose tolerance. To investigate their relations and discuss whether CHD patients with abnormal glucose metabolism exist endothelial dysfunction and inflammatory state. Methods 96 CHD patients were divided into normal glucose tolerance （NG） group, impaired glucose tolerance （IGT） group and type 2 diabetes mellitus （T2DM） group according to oral glucose tolerance test （OGTT）. Serum concentrations of SVCAM-1 and SICAM-1 and hs-CRP were measured in them and 30 controls, their associations with parameters of glucose metabolism were analyzed. Results Serum concentrations of SVCAM-1 and SICAM-1 and hs-CRP in IGT and T2DM groups were higher than NG and control group, good overall correlations between SVCAM-1 and SICAM-1 and HbAtc were showed（r=0.39,0.51, P〈0.01）, moreover, the same relationships with hs-CRP were showed （r=0.32,0.56,P〈0.01）. Conclusion Increased levels of SVCAM-1 and SICAM-1 and hs- CRP according to the order glucose tolerance groups in CHD patients indicate that endothelium impairment and inflammatory state maybe the important pathophysiological factors in CHD patients with abnormal glucose metabolism.
出处
《中国心血管病研究》
CAS
2014年第1期17-21,共5页
Chinese Journal of Cardiovascular Research
关键词
可溶性血管细胞黏附分子
可溶性细胞间黏附分子
冠状动脉疾病
糖耐量
Soluble vascular cell adhesion molecules
Soluble intercellular adhesion molecules
Coronary heart disease
Glucose tolerance
