摘要
目的探讨血栓前状态分子标志物:抗凝血酶活性(AT:A)、蛋白C活性(PC:A)、蛋白S活性(PS:A)、纤溶酶原活性(PLG)、D二聚体(D-Dimer)、纤维蛋白降解产物(FDP)、狼疮抗凝物(LA)与中国汉族妇女复发性流产(RSA)的关系,及各分子标志物对血栓前状态(PTS)引起的RSA的诊断价值。方法采用免疫散射比浊法、血液凝固法及发色底物法检测512例RSA病史现未孕者及230例健康未孕者血浆中AT:A、PC:A、PS:A、PLG:A、D-Dimer、FDP、LA的变化。结果 RSA组患者的PS:A明显低于对照组(P<0.01),D-dimer、FDP高于对照组(P<0.05),AT:A、PLG:A、PC:A、LA1、LA2%、LAR则无统计学差异(P>0.05)。结论 PS:A、D-Dimer、FDP可能与RSA的发生有关,可作为中国汉族妇女未孕人群是否存在血栓前状态的筛查指标。
Objective To investigate the correlation between prethrombotic state molecular markers, such as antithrombin activ- ity （ AT： A）, protein C activity （ PC ： A）, protein S activity （ PS： A）, plasminogen activity （ PLG： A）, D - Dimer, fibrinogen degradation products （FDP）, lupus anticoagulant （LA）, and recurrent spontaneous abortion of Chinese Han women. Methods The levels of plasma AT：A, PC：A, PS：A, PLG：A, D - Dimer, FDP and LA in 512 RSA patients and 230 normal non - pregnancy women were determined by immunoturbidimetry method, blood coagulation method and developing substrate method. Results In RSA group, the PS ： A level was significantly lower than that in NNP women（P 〈 0.01 ）, while D - dimer and FDP were higher than those in NNP women（P 〈 0.05）. The levels of AT：A, PLG：A, PC：A, LA1 , LA2 and LAR had no statistical difference between RSA group and NNP group （P 〉 0.05）. Conclusion PS： A, D - dimer and FDP are associated with RSA, and they can be screening markers of prethrombotic state for normal non - pregnancy women in Chinese Han population.
出处
《中国卫生检验杂志》
北大核心
2013年第18期3546-3548,共3页
Chinese Journal of Health Laboratory Technology
关键词
复发性流产
血栓前状态
分子标志物
微血栓形成
Recurrent spontaneous abortion
Prethrombotie state
Molecular markers
Micro thrombosis
