摘要
目的:采用静息态功能磁共振成像研究肝性脑病患者全脑功能网络连接改变机制。方法:采集13例慢性肝硬化肝性脑病患者和17例健康志愿者的静息态血氧依赖水平功能磁共振成像(BOLD-fMRI)数据,采用自动化解剖标记(AAL)模板计算90个脑区的两两间功能连接情况。结果:肝性脑病患者有15条功能连接出现异常,其中12条功能连接显著下降(P<0.01),3条显著升高(P<0.01),且其中9条异常连接出现在皮层下区域与皮层区域之间,且改变的功能连接与神经心理学测试存在一定相关性。结论:肝性脑病患者的基底节-丘脑-皮层回路受损,功能连接的改变与肝性脑病患者认知功能的改变有关。
Objective：To investigate the whole brain functional connectivity changes in patients with overt hepatic en- cephalopathy （OHE） using resting-state functional magnetic resonance imaging （rs-fMRI）. Methods： rs-fMRI data were ac- quired in 13 cirrhotic patients with OHE and in 17 healthy volunteers as controls,to study the data of blood oxygen depend- ent levels （BOLD-fMRI）. Using AAL templates the functional connectivity was calculated between each two brain areas in 90 brain regions. Results：There were 15 functional connection abnormalities in OHE patients, with markedly decreased in 12 （P〈0.01） and markedly increased in 3 （P〈0.01）. Nine of the abnormal connections appeared between subcortical and cortical regions. The changed functional connections showed correlation with neuropsychology tests scores. Conclusion：The OHE patients had impairment of basal ganglia-thalamo cortical circuit,the change of functional connection in OHE patients might relate with the impairment of recognition function.
出处
《放射学实践》
2014年第1期21-24,共4页
Radiologic Practice
基金
国家自然科学基金资助课题(81322020
81230032
81101039
81171313
30700194)
江苏省博士后基金资助课题(1002083C)
关键词
肝性脑病
脑功能连接
磁共振成像
Hepatic encephalopathy
Brain functional connectivity
Magnetic resonance imaging
