摘要
目的了解深部真菌感染患者血液中病原菌的分布及耐药性情况。方法对2007年1月至2012年10月在本院诊治的130例深部真菌感染患者的血液实验室检查资料进行回顾性分析。结果分离白念珠菌41株(31.54%)、热带念珠菌29株(22.31%)、近平滑念珠菌26株(20.00%)、马尔尼菲青霉14株(10.77%)、光滑念珠菌13株(10.00%),新生隐球菌4株(3.08%),烟曲霉、镰刀菌和季也蒙念珠菌各1株(0.77%)。入组分析患者多存在血液病、恶性肿瘤、肺部感染等基础性疾病。耐药性分析显示,除有1株菌株对氟康唑耐药外,未发现对两性霉素B、伏立康唑和伊曲康唑耐药的菌株。结论白念珠菌、热带念珠菌、近平滑念珠菌为主要的感染病原菌,分离菌株未发现严重的耐药现象。重症监护病房、儿科、外科及血液科应重视患者深部真菌感染并及时给予检查治疗。
Objective To analyze the species and drug sensitivity of the fungi in blood samples of deep fungal infection patient in our hospital. Methods A retrospective analysis was performed on 130 cases of deep fungal infection cases collected from Jan, 2007 to Dec, 2010 in our hospital. Results Among the 130 cases, the dominant pathogenic fungi in decreasing order were Candida albicans （41,31.54%）, Candida tropicalis （29,22.31%）, Candida parapsilosis （26, 20.00%）, Penicillium marneffei （14,10.77%） and Candida glabrata （13,10.00%）. Meanwhile, Cryptococcus neoformans （4,3.08%） and Aspergillusfumigatus （1,0.77%）, and Fusarium （1,0.77%）, Candida guilliermondii （1,0.77%） were identified. The department of Intensive Care Unit （ICU）, pediatrics, surgery and hematology were predominate departments that fungi were frequently isolated. The blood diseases, malignant tumors and lung infections posed the majority of the diseases of the patients in this study. No resistant strains were identified among the tested antifungal drugs including amphotericin B,voriconazole,and itraconazole except one isolate was resistant to fluconazole. Conclusion Candida albican, Candida tropicalis and Candida parapsilosis were the main pathogens among the 130 cases. No serious resistance isolates were found in this study. The department of ICU, pediatrics, surgery and hematology should pay more attention to deep fungal infection of the patients and provide prompt antifungal therapy.
出处
《热带医学杂志》
CAS
2013年第12期1480-1482,共3页
Journal of Tropical Medicine
关键词
深部真菌感染
血液
病原菌
真菌
耐药性
deep fungal infection
blood
pathogen
fungi
drug resistance
