摘要
目的:从肠管运动功能的角度,探讨中药"十八反"中海藻与甘草配伍禁忌的机制。方法:观察海藻与甘草单煎液、合并液和合煎液对大鼠离体回肠收缩活动的影响,及其单煎液与合煎液对小鼠在体小肠推进功能的影响,分别记录离体回肠收缩张力和在体小肠推进距离,并计算其回肠张力差及小肠推进率。结果:海藻单煎液能浓度依赖性增加大鼠离体回肠的收缩张力,0.1-2mg生药/mL时有显著性差异(P<0.01);与甘草合用后其升高回肠收缩张力的作用显著减弱(P<0.05)。海藻低、中、高剂量(0.78、1.56、3.12g/kg)能显著增加小鼠小肠推进率(P<0.05),而海藻-甘草(1∶1)合煎液对小肠推进率无显著影响。结论:海藻能促进大鼠离体回肠和小鼠小肠运动,当与甘草合用后其生物效应受到明显抑制。甘草可能通过对肠管运动的抑制,产生了抑制海藻"润下"、"利水"的功效,这为海藻与甘草配伍禁忌理论提供了一定实验证据。
Objective： To explore the mechanisms of incompatibility in Glycyrrhizae Radix et Rhizoma （Gancao, GC） and Sargassum （Haizao, HZ） which were included in Traditional Chinese Medicine （TCM） Eighteen Incompatible Medicament. Methods： The effects of HZ combining with GC on the contraction of rat ileum in vitro and on the peristaltic motion of mouse small intestine in vivo were observed. The contractile tension and propulsive distance were recorded. Results： HZ decoction alone （0.1-2mg/mL） significantly increased the contractile tension of rat ileum in a dose-dependent manner （P〈0.01）. This effect was significantly weakened when combined with GC （P〈0.05）. HZ decoction （0.78, 1.56, 3.12g/kg） obviously raised small intestinal propulsive rate （P〈0.05）, while the HZ-GC co-decoction could not increase propulsion. Conclusion： The motility-promoting effect of HZ in rat isolated ileal smooth muscle and mouse small intestine was inhibited when combined with GC, which may be one of the reasons why they are incompatibile.
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2014年第1期87-90,共4页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
国家重点基础研究发展计划(973计划)项目(No.2011CB505303)~~
关键词
海藻
甘草
反药
肠管运动功能
配伍禁忌
Sargassum
Glycyrrhizae Radix et Rhizoma
Intestinal motility
Incompatible medicament
