摘要
目的：建立T〉MIC超过40%的美罗培南给药设计方案。方法：估算患者药动学参数,以T〉MIC达到40%~100%为目标,利用药动学公式和简易数学法设计给药方案,比较实测Cmax、Cmin与预测值的差别,并分别计算药时曲线法和简易数学模拟法下的T〉MIC。结果：患者预测Cmin为（1.6±0.9）μg·ml-1,实际Cmin为（1.8±1.6）μg·ml-1,预测Cmax为（23.2±8.8）μg·ml-1,实际Cmax为（26.8±13.3）μg·ml-1,预测Cmin、Cmax与实际Cmin、Cmax均具有相关性（P〈0.001,r=0.695;P〈0.001,r=0.874）;患者药时曲线模拟法的T〉MIC与简单数学模拟法的T〉MIC具有高相关性（P〈0.001,r=0.968）,校正公式为：Y=1.116 X-12.28。30例患者中仅有2例的T〉MIC没有达到目标范围。结论：本方案简便,快捷,可用于临床美罗培南个体化给药方案的设计及评价。
OBJECTIVE To establish meropenem dosage regimens based on T〉MIC of 40% - 100%. METHODS The pharmacokinetic parameters of patients were estimated, meropenem dosage regimes were designed according to pharmacokinetic parameters and T〉MIC of 40% - 100%. T〉MIC was calculated by simple mathematical simulation and concentration-time curves simulation. Predicted Cram and Cmax were compared with observed Cmin, and Cmaxrespectively. T〉MIC calculated by simple mathematical simulation was compared to that calculated by concentration-time curves simulation. RESULTS Predicted Cmin and Cmax were （1.6 ± 0.9） /μg.ml -1 and （23.2 -± 8.8） μg.ml-1 respectively, observed Cmin and C were （1. 8 ± 1.6）μg.ml / and（26. 8 ± 13.3）μg. ml-1, respectively. There was correlation between predicted values and measured values. Correlation was also found between T〉MIC calculated by simple mathematical simulation and by concentration time curves simulation. Correction formula was Y = 1.116X- 12.28. In all 30 patients, only two patients＇ T〉MIC Was out of the target range. CONCLUSION The established dosage regimens of meropenem was convenient, it was suitable for individual dosage regimen design of meropenem based on T〉MIC.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2014年第1期69-73,共5页
Chinese Journal of Hospital Pharmacy
基金
长沙市科技计划项目(项目编号:K1301012-31)
