摘要
目的探讨腹膜胶质瘤病(GP)的临床病理特征。方法对一例GP进行组织形态学、免疫组化分析,并复习相关国内、外文献。结果 CT示腹腔内从肾中极层面至骨盆入口处层面见一巨大体积类园形高低混杂密度影。术中见巨大囊实混合性肿瘤,肿瘤来源于左卵巢,大小约30 cm×20 cm×10cm,包膜完整,分叶状;大网膜、腹壁上有大量弥散小结节,约绿豆大小,质硬。镜下见肿物由三胚层组织组成,含大量成熟的神经胶质组织。大网膜、腹壁上密集粟粒样结节,镜下均为成熟的神经胶质组织,边界清楚,无浸润。免疫组化:腹膜神经胶质结节Leu7(+)、GFAP(+)、S-100(+)、Vimentin(+),结节表面被覆的间皮细胞CK(+)。结论 GP是一种罕见疾病,大部分对预后无不良影响,但可恶变,需长期随访。
Objective To study the clinicopathological features of g]iomatosis peritonei （GP）. Methods Aease of GP was analyzed by light microscopy and immunohistoehemistry and related literatures were reviewed. Results A 14-year-old girl with abdominal distension for 2 years and pain for 20 days. CT shows a huge, round mass of mixed height in the abdominal cavity form the central surface of the kidneys to the entrance of the pelvis. During the operation, a huge mixed tumor of cystic was seen form the left ovary. It measured 30 cmx 20 em x 10 cm with complete capsule, phylloides. Numerous hard nodules, as small as mung beans, were noted on the surface of the capsule and stomach. Micros copieally, the tumor was composed of epidermal, meso- dermal elements with large amounts of glial tissue. Numerous omental nodules on the capsule were composed of mature glial tissue with clear border and no infiltration. Immunohistoehemistry ： glial fibriUary acid protein Leu7 （ ＋ ） , GFAP（ ＋ ） , S-100 （ ＋ ） , Vimentin （ ＋ ）, Cytokeratin was positive in the mesothelial cells covering the nodules. Conclusion GP is an extremely rare disease which has no adverse effect on the prognosis, but needs a long-term foUow-up because of its potential of malignant transformation.
出处
《中国现代药物应用》
2014年第1期9-10,共2页
Chinese Journal of Modern Drug Application
关键词
腹膜胶质瘤病
卵巢畸胎瘤
临床病理
Gliomatosis peritonei
Ovarian teratoma
Clinical pathology
