摘要
目的 :探讨姜黄素 (Curcumin ,Cur)清除羟自由基及防御脂质过氧化的能力。方法 :利用Fenton反应生成羟自由基 (OH) ,由AAPH诱发红细胞氧化性溶血。结果 :姜黄素对羟自由基有较强的清除作用 (SC50 为 58.8μmol/L) ,其作用超过OH的特异性清除剂甘露醇 (SC50 为 2 1 .3μmol/L) ;姜黄素 ( 1 2 0 μmol/L)能有效地抑制由AAPH诱发的红细胞氧化性溶血 (抑制 2h以上 ) ,显示了较强的防御脂质过氧化的能力。结论
OBJECTIVE:To study the effect of curcumin(Cur) on hydroxyl free radical(OH) and oxidative hemolysis in mouse erythrocytes.METHODS:To produce the OH by fenton reaction and induce the oxidative hemolysis in mouse erythrocytes by AAPH.RESULTS:Cur was found to significantly scavenge the OH(SC 50 =58.8μmol/L),and the scavenging effect of Cur was obviously stronger than that of mannitol,a specific OH scavenger(SC 50 =21.3μmol/L).Cur(120μmol/L) was also shown to have strong inhibitory effect on erythrocytes oxidative hemolysis(the hemolysis was inhibited for more than 2h).CONCLUSION:It suggested that the anticancer and antiinflammation activity of Cur,may be related to its scavenging effects on oxygen free radicals and the inhibitory effect on lipid peroxidation.
出处
《中国现代应用药学》
CAS
CSCD
2000年第6期469-471,共3页
Chinese Journal of Modern Applied Pharmacy
关键词
姜黄素
羟自由基
红细胞溶血
curcumin,hydroxyl free radical,erythrocytes hemolysis
