摘要
目的研究慢性肾衰竭血尿酸水平与急性ST段抬高心肌梗死患者预后的关系。方法选择慢性肾衰竭合并高尿酸血症患者作为观察组、慢性肾衰竭未合并高尿酸血症患者作为阴性对照组、肾功能正常的高尿酸血症患者作为阳性对照组,观察发生心肌梗死的例数、检测心功能相关指标、评估负面情绪,并对心肌梗死发生的相关因素进行logistic回归分析。结果慢性肾衰竭不同分期均存在高尿酸血症,其表达水平明显高于肾功能正常组;心肌梗死的发生与高尿酸血症、贫血、营养不良、高血压、异位钙化、抑郁情绪呈正相关。观察组左心室舒张末期直径、射血分数明显低于对照组,发生心肌梗死的例数、ST段抬高程度、HAMD评分、HAMA评分、VAS评分均明显高于对照组。结论高尿酸血症是慢性肾衰竭诱发心肌梗死的危险因素,会对心功能造成不同程度的损害。
Objective To study the relationship between serum uric acid level in chronic renal failure（CRF） and the prognosis of ST-segment elevation myocardial infarction（STEMI）. Methods The patients with CRF compli- cating hyperuricemia were selected as the observation group, the patients with CRF and without comlicating hyperuri- cemia as the negative control group and the patients with normal renal function and hyperuricemia as the positive con- trol group. The cases of STEMI occurrence were observed. The cardiac function related indexes were detected and the negative emotions were evaluated. The related factors of STEMI occurrence were performed the Logistic regression a- nalysis. Results Hyperuricemia existed in different stages of CRF,its expression level was significantly higher than that in the normal renal function group;the occurrence of STEMI had the positive relationship with hyperuricemia, a- nemia,malnutrition, hypertension, eetopic calcification and depression; LVEDD and LVEF in the observation group were significantly lower than those in the control group, while the cases of myocardial infarction occurrence, ST seg- ment elevation degrees and the scores of HAMD, HAMA and VAS were significantly higher than those in the control group. Conclusion Hyperuricemia is a risk factor of myocardial infarction induced by CRF,and can cause the damage of cardiac function to different degrees.
出处
《检验医学与临床》
CAS
2014年第1期57-58,61,共3页
Laboratory Medicine and Clinic
