期刊文献+

血尿酸与老年女性冠状动脉病变的相关性研究 被引量:4

下载PDF
导出
摘要 目的观察老年女性血尿酸水平与冠状动脉病变的相关性。方法选取经冠状动脉造影证实的126例冠心病患者(冠状动脉狭窄大于50%),并选110例冠状动脉正常者作为对照组。采用尿酸酶法测定血尿酸(UA),同时监测体质量指数(BMI),测定空腹血糖(FPG)、三酰甘油(TG)和总胆固醇(TC)等相关指标。结果冠心病组UA浓度明显高于对照组,差异有统计学意义(P<0.01),冠心病组中急性冠状动脉综合征UA浓度明显高于稳定性心绞痛组,差异有统计学意义(P<0.01)。冠状动脉三支病变组、双支病变组及单支病变组UA浓度明显高于对照组,差异有统计学意义(P<0.01);三支病变组UA水平明显高于单支病变组,差异也有统计学意义(P<0.01),也高于双支病变组,差异也有统计学意义(P<0.05);双支病变组UA水平高于单支病变组,差异有统计学意义(P<0.05)。结论血尿酸参与老年女性冠状动脉粥样硬化病变的发生发展,冠心病患者血尿酸升高,且其浓度变化与动脉粥样硬化斑块的稳定性和病变程度有关。
作者 袁帅 刘福颂
出处 《检验医学与临床》 CAS 2013年第9期1133-1135,共3页 Laboratory Medicine and Clinic
  • 相关文献

参考文献11

  • 1Lim HE, Kim SH, Kim EJ, et al. Clinical value of serum uric acid in patients with suspected coronary artery dis ease[J]. Korean J Intern Med,2010,25(1) :21-26. 被引量:1
  • 2孙志宏,李淼,高爱玲,党瑜华.血清尿酸水平与冠心病相关性研究[J].中华实用诊断与治疗杂志,2010,24(9):873-874. 被引量:17
  • 3Brodov Y,Behar S,Boyko V,et al. Effect of the metabolic syndrome and hyperuricemia on outcome in patients with coronary artery disease (from the Bezafibrate Infarction Prevention Study)[J].Am J Cardiol, 2010,106(12): 1717-1720. 被引量:1
  • 4Car S,Trkulja V. Higher Serum uric acid on admission is associated with higher short-term mortality and poorer long-term survival after myocardial infarction: retrospec- tive prognostic study[J]. Croat Med J, 2009,50 ( 6 ) : 559- 566. 被引量:1
  • 5Braunwald E, Antman EM, Beasley JW, et al. ACC/AH A guidelines for the management of patients with unstable angina and non-SF segment elevation myocardial infarc- tion. A report of the American College of Cardiology/A- merican Heart Association Task Force on Practice Guide- lines(Committee on the Management of Patients with Un- stable Angina) [J]. J Am Coil Cardliol, 2000,36 (3) : 970- 1062. 被引量:1
  • 6Cai H, Harrison DG. Endothelial dysfunction in cardio- vascular diseases:the role of oxidant stress [J].Cir Res, 2000,87(10) :840-844. 被引量:1
  • 7Bagnati M, Perugini C,Cau C,et al. When and why a wa- ter-soluble antioxidant becomes pro-oxidant during cop- per-induced low-density lipoprotein oxidation: a study u- sing uric acid[J].Biochem J, 1999,340(1) : 143-152. 被引量:1
  • 8Watanabe SD,Feng L. Uric acid, hominoid evolution,and the pathogenesis of salt-sensitivity [J]. Hypertension, 2002,40(3) :355-360. 被引量:1
  • 9Ioachimescu AG,Brennan DM, Hoar BM, et al. Serum uric acid is an itidependent predictor of all-cause mortality in patients at high risk of cardiovascular disease:a preven- tive cardiology information system(PreCIS) database co- hort study[J]. Arthritis Rheum, 2008,58 (2) : 623-630. 被引量:1
  • 10车玉英,郭琳,周永超,李超民,杨瑜莹,贺东风,罗微.急性冠脉综合征患者血尿酸变化的临床意义[J].第四军医大学学报,2007,28(2):139-139. 被引量:25

二级参考文献16

共引文献42

同被引文献39

  • 1张志辉,周胜华,祁述善,李旭平.氧化应激、炎症与冠心病患者冠状动脉斑块的关系[J].中南大学学报(医学版),2006,31(4):556-559. 被引量:22
  • 2寿涛,李芹,林俊,郑红梅,张虹,毕丹艳,梅坚,和芳,严新民.类风湿关节炎发生动脉粥样硬化的机制研究[J].中华风湿病学杂志,2006,10(9):558-560. 被引量:31
  • 3刘健,范海霞,杨梅云.新风胶囊治疗类风湿性关节炎的临床研究[J].中国中医药科技,2007,14(6):389-391. 被引量:6
  • 4孙晓燕.年龄及性别对冠心病患者尿酸水平的影响.河北医科大学,2009. 被引量:1
  • 5Goodarzynejad H,Anvari MS,Boroumand MA,et al.Hyperuricemia and the presence and severity of eorormry artery disease.Lab Med,2010,41:40-45. 被引量:1
  • 6Sinan Deveci O,Kabakci G,Okutucu S,et al.The association between flemm uric acid level and coronary artery disease.Intern J Clin Pmct,2010,64:900-907. 被引量:1
  • 7Gensini GG.A more meaningful scoring system for determ ining the severity of coronary heart disease.Am J Cardiol,1983,51:606. 被引量:1
  • 8Bickel C,Rupprecht HJ,Blanford S.serum acid as an independent Predictor of mortality in patients with angiographically provencoronary artery disease.Am Cardiol,2002,89:12-17. 被引量:1
  • 9Rothenbacher D,Kleiner A,Koenig W,et al.Relationship between inflammatory cytokines and uric acid levels with adverse cardiovascular outcomes in patients with stable coronary heart disease.PLo S One,2012,7:e45907. 被引量:1
  • 10Kanbay M,Sánchez-Losada LG,Franco M,et al.Microvascular disease and its role in the brain and cardiovascular system:a potential role for uric acid as a cardiorenal toxin.Nephrol Dial Transplant,2011,26:430-437. 被引量:1

二级引证文献41

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部