摘要
目的探讨降钙素原(PCT)和白细胞介素6(IL-6)在新生儿肺炎早期诊断中的应用价值。方法采用电化学发光法测定新生儿细菌感染性肺炎组患儿血清和健康足月儿脐带血中PCT和IL-6含量,并对两组血清中PCT、IL-6的结果进行统计学分析,观察PCT、IL-6诊断新生儿肺炎的敏感性、特异性、阳性预测值、阴性预测值。结果新生儿细菌感染性肺炎组的PCT、IL-6水平均显著高于非细菌感染性肺炎组和对照组(P<0.01);细菌感染性肺炎组治疗后恢复期PCT、IL-6水平较治疗前显著降低(P<0.01)。Cut-off值为2 ng/mL时,PCT对新生儿细菌感染性肺炎诊断的敏感性、特异性、阳性预测值和阴性预测值分别达85.6%、93.2%、93.1%及82.0%。Cut-off值为84.5 pg/mL时,IL-6对新生儿细菌感染性肺炎诊断的敏感性、特异性、阳性预测值和阴性预测值分别达77.2%、87.6%、58.3%及94.2%。结论血清PCT和IL-6快速测定可作为新生儿肺炎早期诊断的指标。
[Objective ] To explore the value of PCT and IL-6 in early diagnosis of neonatal pneumonia. [Methods] The levels of PCT and IL-6 was determined by the electrochemiluminescence immunoassay （E- CLIA）. The difference were compared between two groups with PCT and IL-6. [Results] The levels of PCT and IL-6 were significantly higher in the neonatal pneumonia group with bacterial infection than that in the neonatal pneumonia group without bacterial infection and control group （P〈0.01）. The levels of PCT and IL-6 were significantly reduced for the neonatal pneumonia with bacterial infection in restoration stage （P〈0.01）. The cut off value of PCT is 2 ng/mL for the diagnosis of the neonatal pneumonia with bacterial infection. The sensitivity, specificity, positive predictive value and negative predictive value were 85.6%, 93.2%, 93.1% and 82.0% respectively. The cut-off value of IL-6 is 84.5 pg/mL for the diagnosis of the neonatal pneumonia with bacterial infection. The sensitivity, specificity, positive predictive value and negative predictive value were 77.2%, 87.6%, 58.3%, 94.2% respectively. [Conclusion] The rapid detection of PCT and IL-6 is valuable for the early diagnosis of the neonatal pneumonia.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2013年第32期100-103,共4页
China Journal of Modern Medicine
