摘要
类风湿性关节炎(rheumatoid arthritis,RA)被喻为是不死的癌症,因其发病过程累及多系统,涉及的细胞因子、蛋白等生物分子众多,故其具体的发病机制至今仍未阐明。近年来,Wnt通路在RA中对炎症、软骨和骨等方面发挥的作用逐渐被证实,这些发现不仅为深入研究RA的发病机制提供新思路,而且为防治RA疾病的药物研究提供了新靶点。
Rheumatoid arthritis （RA） is defined as deathless cancer. The specific mechanism still remains to be expounded, as it involes several systems and a lot of cytokines, proteins, etc. In recent years, roles of Wnt signaling pathway in inflamma- tion, cartilage, bone and other aspects in RA have been clarifiedgradually. These findings not only provide new thinking for deep exploration in pathogenesis of RA, but also offer novel target spots for drug developing in preventing RA.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2014年第1期13-16,共4页
Chinese Pharmacological Bulletin
基金
国家自然科学基金面上项目(No 81373499)
广东省科技计划项目(No 2011B031800248)
关键词
类风湿性关节炎
WNT通路
骨损害
软骨损害
破骨
细胞
成骨细胞
rheumatoid arthritis
Wnt signaling pathway
bonedestruction
cartilage destruction
osteoclast
osteoblast
