摘要
[目的]研究除草剂氟丙嘧草酯的合成方法。[方法]以2-氯-5-硝基苯甲酸为初始原料,经酯化、还原、异氰酸化、环合即得目标产物氟丙嘧草酯。[结果]在优化的反应条件下,反应总收率为57%(以2-氯-5-硝基苯甲酸计),纯度99%;产物结构经HPLC-MS、1H NMR确证。[结论]该反应条件温和,操作简便,适合在工业上推广应用。
[Aims] This article aims to study the synthetic method of butafenacil. [Methods] Butafenacil was synthesized from 2-chloro-5-nitrobenzoic acid via esterification, reduction, isocyanation and cyclization. [Results] Under the optimal reaction conditions, the total yield of butafenacil was 57% based on 2-chloro-5-aminobenzoic acid, the purity was 99%. The structure was confirmed by HPLC-MS and ＇H NMR. [Conclusions] This method is suitable for industrial production with advantages of mild reaction condition and simple operation.
出处
《农药》
CAS
CSCD
北大核心
2014年第1期12-14,共3页
Agrochemicals
