摘要
目的观察化疗对卵巢癌患者淋巴细胞亚群的影响。方法收集湖北省鄂州市中心医院自2007年1月—2013年3月间收治的卵巢癌患者62例，以同期门诊体检的健康妇女60例作为健康对照组。分别检测卵巢癌组化疗前及化疗后一周、一个月和对照组外周血淋巴细胞CD3、CD4、CD8及CD25的表达，分析各淋巴细胞亚群情况。结果卵巢癌患者外周血CD3＋、CD4＋细胞的比例以及CD4＋／CD8＋的比值均较正常对照组显著降低，差异有统计学意义（P〈0．05）；而CD4＋CD25＋细胞的比例较对照组显著增高（P〈0．05）；化疗前不同临床分期卵巢癌患者外周血淋巴细胞亚群之间差异无统计学意义（P〉0．05）。卵巢癌患者化疗后一周上述指标无显著改变（P〉0．05）；而化疗后一个月时上述指标较化疗前显著改善（P〈0．05）；有效组患者化疗后一个月时上述指标显著优于无效组（P〈0．05）。结论卵巢癌患者外周血淋巴细胞亚群存在比例失调，动态监测其变化有助于指导治疗及对疗效和预后进行判断。
Objective To observe the effects of chemotherapy on the peripheral blood lymphocyte sub- cluster in patients with ovarian cancer. Methods Sixty - two patients with ovarian cancer who accepted chemo- therapy from Jan 2007 to Mar 2013 in our hospital were collected. Sixty healthy women in our hospital were used as control. The expressions of CD3, CD4, CD8 and CD25 in peripheral blood lymphocyte of ovarian cancer patients before ,one week and one month after chemotherapy and healthy women were detected and analyzed. Results The ratio of CD3 ~ and CD4 ~ T ceils and CD4 ~/CD8 ~ in patients with ovarian cancer were significantly lower than those in healthy. Whereas the ratio of CD4 ~ CD25 ~ T cells in patients with ovarian cancer was significantly higher than that in healthy women. No significant differences were observed in ovarian cancer patients with differ- ent clinical stage. There were no significant changes that observed one week after chemotherapy in patients with o- varian cancer. These indexes improved notably one month after chemotherapy. These indexes in effective group one month after chemotherapy were significantly better than those in inefficient group. Conclusion The ratio of pe- ripheral blood lymphocyte sub - cluster in patients with ovarian cancer was imbalance. Dynamic monitoring the changes could guide the therapy and judge the curative effect and prognosis.
出处
《实用肿瘤学杂志》
CAS
2013年第6期539-542,共4页
Practical Oncology Journal
关键词
卵巢癌
化疗
淋巴细胞亚群
Ovarian cancer
Chemotherapy
Lymphocyte sub -cluster
