摘要
纳洛酮是一种人工合成的阿片受体拮抗剂,可以拮抗和逆转阿片药物的全部药理作用,是阿片药物过量救治的标准药物和特效治疗药物,用于治疗阿片药物过量所致的昏迷和呼吸抑制。近年研究显示,纳洛酮在缓解长期应用阿片药物所致便秘方面,也有突出的疗效。还有研究发现,应用超低剂量纳洛酮可以增强阿片药物止痛效果,减少阿片药物消耗量。本文对纳洛酮在癌痛治疗中的这些应用与研究进展进行综述。
Naloxone is a synthetic pan-opioid receptor competitive antagonist of the opioid receptors inside and outside the cen-tral nervous system. After systemic administration, it reverses almost all opioid effects. Systemically administered naloxone is used to reverse the life-threatening opioid toxicity. A number of studies have analyzed the importance of oral naloxone as a peripheral opioid an-tagonist in cancer patients. Naloxone has shown satisfactory efficacy for opioid-induced constipation （OIC）. Ultra-low dose of naloxone has been reported to enhance the anti-nociceptive effect of morphine and reduce morphine consumption. We summarize the results from current studies of naloxone administration in cancer pain management.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2013年第24期1487-1491,共5页
Chinese Journal of Clinical Oncology
关键词
阿片药物
纳络酮
癌痛
便秘
opioids, naloxone, cancer pain, constipation
